Myasthenia gravis is characterized by Right Ans - fatigue and descending
muscle weakness
MG typically improves following Right Ans - rest.
first sign of MG is Right Ans - droopy eyes
what are the clinical types Right Ans - 1. ocular myasthenia gravis
2. generalized myasthenia gravis (most concerning to us)
ocular myasthenia gravis Right Ans - limited to the eyelids and extra ocular
muscles
myasthenia graves is the most common CHRONIC DISORDER of the Right
Ans - neuromuscular junction
generalized myasthenia graves involves Right Ans - muscles of the mouth
and throat
limbs
respiratory muscles
may have dropped head syndrome
since mg affects only the motor junction Right Ans - sensory function is not
lost (but not as painful as GBS)
myasthenic crisis is when Right Ans - diaphragmatic paralysis and
ventilary failure develop
less than what % of mg patients will require mech vent Right Ans - 25%
anatomic alterations of the lung: Right Ans - mucous accumulation
airway obstruction
alveolar consolidation
atelectasis
, myasthenia gravis is what type of disease Right Ans - progressive
autoimmune neuromuscular disease
cause of mg appears to be related to Right Ans - acetylcholine (ach)
receptor antibodies (IgG antibodies) that block the nerve impulse
transmissions at the neuromuscular junction
muscles will be best in the (time of day) Right Ans - morning
affects about Right Ans - 36,000-60,000 in the usa
MG is most common in Right Ans - young women 15-35
older men 40-70
clinical manifestations of mg are provoked by Right Ans - emotional upset
physical stress
exposure to extreme temp changes
febrile illness
pregnancy
mortality rate Right Ans - 3% same as GBS
clinical history of pt will be Right Ans - -facial muscle weakness
-ptosis (droopy eye or eyes)
-diplopia (double vision)
-ophthalmoplegia (paralysis or weakness of one or more of the muscles that
control eye movement)
hallmark of myasthenia gravis is Right Ans - CHRONIC muscle fatigue
pt can have difficulty in Right Ans - -breathing, speaking, chewing,
swallowing
-unstable gait
-weakness in limbs and fingers and neck brought on by repetitive use
early signs and symptoms can be Right Ans - elusive (come and go)
onset can be Right Ans - subtle, intermittent, or sudden and rapid
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