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MYASTHENIA GRAVIS – Questions & Accurate Answers
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MYASTHENIA GRAVIS – Questions & Accurate Answers
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MYASTHENIA GRAVIS – Questions & Accurate AnswersWhat is myasthenia Gravis Right Ans - Auto immune dz that attacks the
receptor sites of Ach in the neuromuscular junction. T cells are attacking these
receptors in turn causing m muscle contraction. Only effects skeletal muscle-
NOT smooth muscle of organs like bladder or heart
Who is at risk for getting myasthenia gravis Right Ans - Women ages 20-
30's men 60-70, may occur in association with a thymic tumor, thyrotoxicosis,
rheumatoid arthritis or lupus
What are manifestations of myasthenia gravis Right Ans - Extreme
muscular weakness & easy to fatigue-SYMMETRICALLY involved. Gets worse
with activity and improves with rest. Leg weakness is less common, but can
progress to walking difficulty. Weakness and easy fatigue of arm and hand
muscles. Progressive weakness of diaphragm, intercostal and abdominal
muscles. DOES NOT ALTER INTELLECTURAL FUNCTIONING OR AWARENESS
Where does myasthenia gravis effect first Right Ans - The eye muscles
s/s=diplopia, ptosis
What is bulbar myasthenia Right Ans - Involves the cranial nerves with
facial and oropharyngeal muscle weakness: chewing & swallowing problems,
blank, masklike expression, laryngeal involvement, dysphonia (abnormal
sounding voice), nasal sound, distorted smile "myasthenia snarl"
How do you dx MG Right Ans - H&P and s/s may be definitive, blood tests
show + antibodies to Ach receptors, EMG, CXR and CT diagnose thymoma,
tensilon test
What medication is used in the tensilon test Right Ans - Edrophonium
chloride
What does Edrophonium chloride do Right Ans - Decreases amount of
cholinesterase(inhibits the enzyme that breaks down Ach) at neuromuscular
junction while making Ach avail to muscles and improving muscle
contractility within 30-60 seconds
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