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AOCNP EXAM 2024/2025 WITH 100% ACCURATE SOLUTIONS
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AOCNP EXAM 2024/2025 WITH 100% ACCURATE SOLUTIONS
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AOCNP EXAM 2024/2025 WITH 100%ACCURATE SOLUTIONS
the risk for significant bone marrow suppression (8) - Precise Answer
✔✔advanced age (>65),poor nutritional status, preexisting autoimmune
disease, DM, GI disorders, liver disease, or hematopoietic disease, and
substance abuse.
Cancer-induced bone marrow suppression (3) - Precise Answer ✔✔a)
dysfunctional hematopoietic cell within the bone marrow, b) bone
marrow infiltration with tumor c)general exhaustion of bone marrow
reserves
solid tumor malignancies with the highest propensity to infiltrate the
bone marrow in the course of metastasis - Precise Answer
✔✔melanoma, cancer of the breast, lung, kidney and prostate
Nitrosoureas (Carmustine, Lomustine) - Precise Answer ✔✔affect the
pluripotent stem cell (affecting all cell lines/cell cycle nonspecific agent)
use for glioblastoma multiforme
severe myelosuppression may last up to 85 days, nadir of carmustine
occurs in 26-60 days
Radiation induced bone marrow suppression occurs when (2) - Precise
Answer ✔✔1. treatment field involves marrow producing tissue or with
dose greater than 15 Gy
,CD 4 counts < 500/mm3 - Precise Answer ✔✔significant risk factor for
oopotunisitic infections
Cyclosphosphamide - myelosuppression risk - Precise Answer
✔✔moderate
Paclitaxel - myelosuppression risk - Precise Answer ✔✔moderate
Doxorubicin (Adriamycin) - myelosuppression risk - Precise Answer
✔✔alkylating agnet, may produce severe myelosuppression, the
duration only about 21 days
Myelosupression secondary to radiation therapy peaks at - Precise
Answer ✔✔week 3
Suppression may occur in all cell lines simultaneously rather than
sequentially as seen with chemotherapy
The recovery period also may be less predictable.
Second malignancy : Acute leukemia - potential etiologic factor ? -
Precise Answer ✔✔Alkylating agent, especially with high doses or
cumulative doses of antimetabolites
Antitumor antibiotics
Corticosteroids
Epipodophyllotoxins (i.e Etoposide)
,Second malignancy : Bladder cancer- potential etiologic factor ? -
Precise Answer ✔✔radiation therapy for prostate cancer
Second malignancy : Brain tumors - potential etiologic factor ? - Precise
Answer ✔✔therapeutic radiation for other cancer
Second malignancy : hepatoma- potential etiologic factor ? - Precise
Answer ✔✔Androgen therapy
Second malignancy : Kidney cancer - potential etiologic factor ? -
Precise Answer ✔✔Brain tumor therapies
Cisplatin, especially in treatment for testicular cancer
Second malignancy : Leukemia - potential etiologic factor ? - Precise
Answer ✔✔Antitumor antibiotics
Brest cancer treatment
Lymphoma treatment
Post transplant immunosuppression
Prostate cancer treatment
Second malignancy : Lung cancer - potential etiologic factor ? - Precise
Answer ✔✔HIV infection
Theraputic radiation for other cancers
, Second malignancy : Mesothelioma - potential etiologic factor ? -
Precise Answer ✔✔Thoracic radiation for lung neoplasms
Second malignancy : Neuroectodermal tumors- potential etiologic factor
? - Precise Answer ✔✔Growth hormone replacement after children
cancers
Theraputic radiation for other cancers
Second malignancy : Non-Hodgkin Lymphoma- potential etiologic
factor ? - Precise Answer ✔✔Alkylating agent
Antimetabolites
Antitumor antibiotics
Cyclosporine
Radiation therapy
Tacrolimus
Cumulative radiation dose in excess of ___ Gy reporrted have more
signifiant risk of secondary malignancies - Precise Answer ✔✔30 Gy
Second malignancy : Thyroid cancer- potential etiologic factor ? -
Precise Answer ✔✔Brain tumor therapies
Cisplatin based regimens
Therapeutic radiation
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