Exam (elaborations)
NR566 WEEK 2 EXAM QUESTIONS AND ANSWERS
- Course
- Institution
NR566 WEEK 2 EXAM QUESTIONS AND ANSWERS
[Show more]
Content preview
NR566 WEEK 2 EXAM QUESTIONS ANDANSWERS
Amphotericin B - Answer--polyene macrolide
-broad spectrum antifungal
*HIGHLY TOXIC*
-only given for infections that are progressive and potentially fatal
- given IV only
Amphotericin B Black Box Warning - Answer-should only be used in the setting of a
potentially life-threatening infection
Amphotericin B side effects - Answer--infusion reactions (fever, chills,rigors, nausea,
headache)
-neprhotoxic
-bone marrow suppression
Drug interactions with Amphotericin B - Answer-increased risk for kidney damage when
used with other nephrotoxic drugs such as:
aminoglycosides
cyclsoporine
NSAIDs
Azoles for systemic mycoses - Answer-itraconazole
ketoconazole
fluconazole
voriconazole
posaconazole
isavuconazonium
Itraconazole (Sporanox) - Answer--alternative to amph b for systemic mycoses
- safer; oral dosing
- adverse effects cardiosupporession and liver injury
-causes transient decrease in EF
-administration with cola enhances absorption
Itraconazole Black Box Warning - Answer-negative inotropic actions; should not be
used for superficial fungal infections, patients with HF, hx of HF or other indications of
ventricular dysfunction
Drug interactios with Itraconazole - Answer--cyclosporine
-warfarin
-sulfonylurea-type oral hypoglycemics
-digoxin
, -quinidine
-give antacids 1 hour before or 2 hours after
Prescribing Considerations for Azoles - Answer--use with caution in patients with liver
disease
-avoid use with drugs metabolized by cyp3a4:
-warfarin
-cyclosporine
-digoxin
-quinidine
Lifespan considerations for Azoles - Answer-ketoconazole has high potential for
hepatotoxicity; do not use in breastfeeding women
Treatment for tines pedis (athlete's foot) - Answer-Topical ketaconazole (antifungal)
Terbinafine
Treatment for tinea corporis (ringworm) - Answer-Topical anti-fungal medication
Terbinafine
Treatment for tinea cruris (jock itch) - Answer-topical and oral antifungals
Terbinafine
may require systemic anti fungal (clotrimazole); topical or systemic glucocorticoids
Treatment for tinea capitis ("ringworm of the scalp" - Answer-oral griseofulvin for 6-8
weeks
OR
oral terbinafine for 2-4 weeks
**topical tx will not work
Treatment for oral candidiasis - Answer-nystatin, clotrimazole, and miconazole
OR
oral fluconazole or ketoconazole for immunocompromised
Treatment for Aspergillosis - Answer-Voriconazole is tx of choice
Amphotericin B
itraconazole
micafungin
Drug interaction with Voriconazole and Phenobarbital - Answer-SHOULD NOT BE
COMBINED DUE TO CYP450
Phenobarbital is a CYP450 inhibitor which can reduce levels of drugs like voriconazole
Diagnostics and Monitoring for antihelmintics - Answer--goal is to eradicate parasitic
worm -infection
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller biggdreamer. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $11.49. You're not tied to anything after your purchase.
Can Stuvia be trusted?
4.6 stars on Google & Trustpilot (+1000 reviews)
78310 documents were sold in the last 30 days
Founded in 2010, the go-to place to buy study notes for 14 years now