CLIN MED: ALLERGY TESTING
QUESTIONS AND ANSWERS WITH
SOLUTIONS 2024
Types of allergies: - ANSWER Type I,II,III, IV
Type I allergy - ANSWER Reaction mediated by IgE antibodies
Example of type I allergy - ANSWER Food, meds, environmental
Type II allergy - ANSWER Cytotoxic reaction mediated by IgG or IgM antibodies
Type III allergy - ANSWER Reaction mediated by immune complexes
type IV allergy - ANSWER Delayed reaction mediated by cellular response
Testing for type I allergens - ANSWER Prick/puncture technique
Intradermal technique
Indications of type I allergy testing - ANSWER Allergic asthma
Rhinitis
Conjuctivitis
Food allergy
Some meds
Venom allergy
Latex
Contraindications of type I allergy testing - ANSWER Significant history of anaphylaxis
, Challenge tests can also be used after allergen is identified by prick test or history for this type of allergy -
ANSWER Type I
Food skin tests, only about 50% are - ANSWER True positives
Some meds need to be stopped prior to testing
Prick testing: reaction occurs within - ANSWER 15 minutes
Various panels of prick testing - ANSWER Outdoor
Foods
Medications
Based on history
Prick testing: control of what substances are used - ANSWER Saline and histamine
Positive prick tests should show - ANSWER Wheal
Intradermal testing - ANSWER Typically used after prick testing to confirm and grade response
Serum IgE testing is done to look for - ANSWER Specific antibody in serum
Serum IgE testing is best for what kind of allergies - ANSWER Food
Serum IgE testing can give false positives in patients with - ANSWER Previous immunotherapy or high levels
of IgE
Serum IgE testing can be useful if what tests can't be performed - ANSWER Prick or Intradermal
Most common allergens: indoor/outdoor - ANSWER Tree, grass, weed pollen, cat and dog dander, mold
spores, mites, cockroaches
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