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Test Bank for Basic and Clinical Pharmacology, 14th Edition by Bertram G. Katzung, 9781259641152, Covering Chapters 1-66 | Includes Rationales$17.99
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Test Bank for Basic and Clinical Pharmacology 14th Edition by Bertram G. Katzung Chapters 1 - 66 Complete
TEST BANK For Basic and Clinical Pharmacology, 14th Edition by Bertram G. Katzung, Verified Chapters 1 - 66, Complete
TEST BANK For Basic and Clinical Pharmacology, 14th Edition by Bertram G. Katzung, Verified Chapters 1 - 66, Complete
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Test Bank for Basic and Clinical Pharmacology, 14th Edition by
Bertram G. Katzung, 9781259641152, Covering Chapters 1-66
| Includes Rationales
Treatment of superficial fungal infections caused by dermatophytic fungi may be accomplished with
the use of? - ANSWER: 1. topical antifungal agent
2. oral antifungal agent
Topical imidazole coverage - ANSWER: wide range of activity against:
Dermatophytes (Epidermophyton, Microsporum, and Trichophyton)
and
Yeasts, including Candida albicans and Pityrosporum orbiculare
Topical imidazole coverage - ANSWER: Dermatophytes and yeasts
Topical imidazoles used in vulvovaginal candidiasis? - ANSWER: Miconazole and Clotrimazole
available as a cream or lotion and as vaginal cream or suppositories - ANSWER: Miconazole
available as a cream or lotion and as vaginal cream and tablets - ANSWER: Clotrimazole
treatment of onychomycosis of the toenails - ANSWER: Efinaconazole (EFIctive for onychomycosis)
How long is the medication for onychomycosis using Eficonazole? - ANSWER: 48 weeks
available as a cream and lotion for topical use - ANSWER: Econazole and Oxiconazole
available as a cream for topical treatment of dermatophytosis and candidiasis and as a shampoo or
foam for the treatment of seborrheic dermatitis. - ANSWER: Ketoconazole
treats dermatophytosis, candidiasis and seborrheic dermatitis? - ANSWER: Ketoconazole
available as a cream - ANSWER: Luliconazole and Sertaconazole
available as a cream or solution - ANSWER: SULConazole (SULotion & Cream)
Why are topical antifungal-corticosteroid fixed combinations have been introduced? - ANSWER: to
provide more rapid symptomatic improvement than an antifungal agent alone.
2 is better than 1.
, Example of topical antifungal-corticosteroid fixed combination? - ANSWER: Clotrimazole-
betamethasone
How frequent do you need to apply certain topical antifungals to clear specific fungal infections? -
ANSWER: 1x- or 2x-daily : clears superficial dermatophyte (for 2-3 wks using any of antifungals)
3x or 4x daily : clears paronychial and intertriginous candidiasis
AE of topical imidazoles? - ANSWER: stinging, pruritus, erythema, and local irritation.
Allergic contact dermatitis is uncommon.
This is a synthetic broad-spectrum antimycotic agent - ANSWER: Ciclopirox olamine
Coverage of Ciclopirox olamine? - ANSWER: activity against dermatophytes, Candida species, and P
orbiculare.
MOA of Ciclopirox olamine? - ANSWER: inhibits the uptake of precursors of macromolecular synthesis
Site of action of Ciclopirox olamine? - ANSWER: probably the fungal cell membrane.
treatment of dermatomycosis, candidiasis, and tinea versicolor - ANSWER: Ciclopirox olamine (1%
cream)
treatment of mild to moderate onychomycosis of fingernails and toenails? - ANSWER: Ciclopirox
olamine (8% cream)
1-2% of the dose is absorbed when applied as a solution at what part of the body? - ANSWER: on the
back under an occlusive dressing.
AE of Ciclopirox olamine? - ANSWER: Pruritus and worsening of clinical disease have been reported.
The potential for allergic contact dermatitis is small.
is the first oxaborole antifungal drug approved for the treatment of toenail onychomycosis. -
ANSWER: Tavaborole
MOA of Tavabarole? - ANSWER: blocks fungal protein synthesis by inhibiting aminoacyl-transfer
ribonucleic acid synthetase.
treatment of toenail onychomycosis - ANSWER: Tavaborole (5% solution) 1x daily for 48 weeks
are allylamines that are highly active against dermatophytes but less active against yeasts. - ANSWER:
Naftifine hydrochloride and terbinafine
Naftifine hydrochloride and terbinafine coverage? - ANSWER: Dermatophytes
Can Naftifine hydrochloride and terbinafine clear infections caused by yeast? - ANSWER: No. It is only
active against Dermatophytes
MOA of Naftifine hydrochloride and terbinafine? - ANSWER: selective inhibition of squalene
epoxidase, a key enzyme for the synthesis of ergosterol
treatment of dermatophytosis? - ANSWER: Naftifine hydrochloride and terbinafine (1% creams) 2x
daily for 1-2 weeks
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