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MCBM 1- (10) Microtubules Questions and Answers 100% Correct
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MCBM 1- (10) Microtubules Questions and Answers 100% CorrectMCBM 1- (10) Microtubules Questions and Answers 100% CorrectMCBM 1- (10) Microtubules Questions and Answers 100% CorrectMCBM 1- (10) Microtubules Questions and Answers 100% CorrectMCBM 1- (10) Microtubules Questions and Answers 100% Correc...

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  • August 18, 2024
  • 3
  • 2024/2025
  • Exam (elaborations)
  • Questions & answers

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  • mcbm 1 10 microtubules questions and answers 10
  • mcbm 1 10 microtubules questions and answers
  • what are microtubules made up of answer alph

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MCBM 1- (10) Microtubules Questions
and Answers 100% Correct
What are microtubules made up of? - ANSWER - -alpha and beta tubulin = dimer.
-dimers come together to form a protofilament
-13 protofilaments = microtubule.


Discuss polarity in regards to structure of microtubules. What is positive and negative? Where
are they found? What end grows? - ANSWER - Alpha is the (-), Beta is the (+) end. Although
there is no chemical polarity, this is said to be polar.


All beta tubulins are at the top, all of the alpha tubulins are at the bottom.


The Beta (+) end grows while the (-) end is non growing.


Discuss tubulin and its relationship to GTP. - ANSWER - Alpha and beta tubulin are always
bound to a GTP or a GDP.


Depolymerization: takes off dimer


GTP tubulin has a high affinity for the plus end of a microtubule.


When the dimer is bound to a GTP, it has a high affinity for for other dimers with GTP. When it
loses a phosphate and turns into a GDP, it loses its affinity and falls off. This goes on and on in
an attempt to balance.


Why are microtubule based cancer drugs effective? - ANSWER - Because microtubules play
such an important role in cell division, they are targeted.


Taxanes: Stabilizes microtubules. In interphase, they are not allowed to depolymerize so
spindles cannot be formed.

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