Textbook notes corresponding to weekly reading guide of Biochemistry course (code BIOSCI98) at University of California, Irvine. Comes with reading guide and a hand-made diagram. Week 3.
Wk3RG
Thursday, January 24, 2019 1:21 AM Abbreviation key:
b/w = between
w/ = with
Ex. = For example,
Wk3RG
Unfolded Protein
Trapped in closed complex
• Quaternary structure: result from interactions b/w subunits of multimeric proteins.
Hsp40
• Oligomeric (multi-subunit) proteins may form when unstable proteins interact w/ other proteins, serving as Triggers ATP
hydrolysis
versatile inhibitors or components of networks. Quaternary assembly assisted by Hsp70 & 40 chaperones. Closed Hsp70-ADP
Once proteins are released,
some will take up native
• Denaturation: the loss of a 3D protein structure, which leads to a loss of function. Mostly exist in a set of partially conformation
folded states.
• Cellular proteostasis1 requires coordinated function of pathways for protein synthesis/folding, refolding of proteins
partially unfolded, and isolation/degradation of unneeded proteins.
○ Proteostasis: the continual maintenance of an active set of cellular proteins required under a given set of
conditions. Maintains proteome of a cell.
• **Process of stepwise folding (hierarchical): small regions of secondary structure are assembled first and then
gradually incorporated into larger structures (ionic interactions important for early steps). Followed by longer-
range interactions b/w two secondary structures--> stable, folded structures. Domains form and the entire protein
is folded.
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