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CMB2004 TEST LATEST UPDATED
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CMB2004 TEST LATEST UPDATED...
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CMB2004 TEST LATEST UPDATEDwhat does immunological tolerance create - ANSWER random generation of
repertoire of BCR and TCR production of self-reactive specificities
types of TCR recognition due to random TCR gene rearrangement - ANSWER -
can't recognise self-MHC (die)
- recognise self MHC and p from Ag in thymus (+ve then eliminated by -ve
selection)
- self MHC and p not in thymus (+ve selection)
what is TCR survival and tolerance based on - ANSWER TCR affinity
need a pop of cells with medium affinity to self-MHC
why do TCR need a medium affinity for self-MHC - ANSWER doesnt give an
autoimmune response
can respond to self-MHC when peptides are derived from AG not present in the
thymus
what happens to T cells that fail +ve selection - ANSWER further rearrangements
of TCRalpha locus
produce different R
Autoimmune Regulator (AIRE) - ANSWER Txn factor
in tolerance induction
expression of tissue-specific Ag in the thymus
deletes T cells recognising them
Deficiency of AIRE - ANSWER autoimmune syndrome
, what happens to self-reactive BCR - ANSWER second chance through receptor
editing
further light chain rearrangement
What are anergic lymphocytes - ANSWER lymphocytes recognise self Ag can
become unresponsive
important in peripheral tolerance
anergic immature B cells - ANSWER R encounter Ag that isnt multivalent
down regulate BCR
what is immunological tolernace - ANSWER Ag not presented at sufficient levels
to activate T cells
eye, testis and CNS
T cell dependent B cell responses - ANSWER if Ag-specific T cells absent
no help is available
no antibody response
Regulatory T cells (Treg) - ANSWER Cd4+ T cell subset
Suppresses immune response through cytokines (TGF-b and IL-10)
prevents autoimmune syndrome IPEX
types of regulatory T cells - ANSWER nTreg-> high affinity for self Ag (thymus)
iTreg-> induced in periphery
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