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PHM 431 Exam 1 | 100 Questions | With Complete Solutions
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PHM 431 Exam 1 | 100 Questions | With Complete Solutions
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PHM 431 Exam 1 | 100 Questions | With Complete Solutions5-hydroxytryptamine is a precursor for the synthesis of what
molecule? Correct Answers melatonin
acetylcholine Correct Answers synthesized from choline and
acetyl coA
-
Active Zones Correct Answers protein accumulation in the pre-
synaptic membrane that is exactly oppose to the post-synaptic
membrane density. This is the site of neurotransmitter release
and the proteins expressed at this zone are all involved in this
process
Adverse events caused by the drug cisapride was a primary
reason for FDA requirements of what drug screen? Correct
Answers HERG potassium channel activity
Agonist Correct Answers a neurotransmitter, hormone or drug
that binds to a receptor and activates that receptor to cause a
response in cells.
agonist Correct Answers neurotransmitter, hormone or drug
that binds to a receptor and activates that receptor to cause a
response in cells
An inhibitor of the enzyme dopamine-beta-hydroxylase will
reduce brain levels of which of the following neurotransmitters?
Correct Answers norepinephrine
, - dopamine is the precursor for norepinephrine synthesis
catalyzed by dopamine-b-hydroxylase
Antagonist Correct Answers a drug that binds to but does not
activate the receptor. Blocks the actions of an agonist.
antagonist Correct Answers drug that binds to but does not
actuvate the receptor, blocks the actions of an agonist
Anterograde transport Correct Answers proteins are transported
from the cell body to nerve terminal
axon Correct Answers - arises from the soma and is able to
propagate electrical signals called action potential from the cell
body to the axon termnal
Axon terminal Correct Answers contains synaptic vesicles
packed with neurotransmitters and the cellular machinery
required for synthesis, storage, release and re-uptake of
neurotransmitters
BoTox Correct Answers - selective for cholinergic nerve
terminals because beta-ganglioside is specific for cholinergic
nerve terminals and is recognized by the heavy chain
BoTox is potentially lethal because: Correct Answers it cleaves
SNARE proteins required for neurotransmitter release
Charybdotoxin Correct Answers blocks K+ channels which are
required for the repolarization phase of action potentials
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