5. Fluoroquinolones - ANS ✓Ciprofloxacin et al
MOA - inhibit DNA gyrase
Use - Gram(-) rods of urinary and GI tract, legionella, neisseria
AE - not for pregnancy, GI, increase seizure risk, tendonitis and Achilles
tendon rupture, prolonged QT
Can't take w/ divalent cations due to impaired absorption
6. Metronidazole - ANS ✓MOA - forms free radials to damage DNA.
Ferredoxin dependent
Use - GET GAP - Giardia, E. histolytica, Trichomonas, Gardinella, Anaerobes,
H. pylori
Use for anaerobes below the diaphragm
AE - Disulfiram like reaction w/ alcohol, metallic taste, teratogen
7. Prophylaxis for M. tb? - ANS ✓Isoniazid
8. Prophylaxis for M. avium-intracellulare - ANS ✓Azithromycin
9. Course for active Tb? - ANS ✓RIPE
Rifampin
Isoniazid
Pyrazinamide
Ethambutol
USMLE Antibiotics
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