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Psychiatry-Pharmacology (USMLE) Exam Questions with Correct Verified Answers Latest Update (2024/2025) Guaranteed Pass
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Psychiatry-Pharmacology (USMLE) Exam Questions with Correct Verified Answers Latest Update (2024/2025) Guaranteed PassPsychiatry-Pharmacology (USMLE) Exam Questions with Correct Verified Answers Latest Update (2024/2025) Guaranteed PassPsychiatry-Pharmacology (USMLE) Exam Questions with Correct Ver...

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  • August 20, 2024
  • 60
  • 2024/2025
  • Exam (elaborations)
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USMLE




Psychiatry-Pharmacology (USMLE)
Exam Questions with Correct Verified
Answers Latest Update (2024/2025)
Guaranteed Pass
1. What nonergot dopamine agonist is used for rescue therapy for
treatment of "off" episodes of akinisia in patients on
dopaminergic therapy? - ANS ✓apomorphine


<i>pre-treatment with antiemetic <b>trimethobenzamide</b>


2. Apomorphine adverse effects (3/6) - ANS ✓QT prolongation


dyskinesias


drowsiness


sweating


hypotension


bruising at the injection site




Psychiatry-Pharmacology (USMLE)

, 2
USMLE

3. Name 2 MAOIs that selectively and <b>IRREVERSIBLY</b>
inhibit MAO-B. - ANS ✓deprenyl (selegiline)
<i>mainly used as adjunct to levodopa; allows dose of levodopa to be
reduced


rasagiline


4. Inhibition of DOPA decarboxylase by carbidopa increases what
peripheral metabolite? - ANS ✓3-o-methylDOPA


5. What COMT inhibitor is associated with fulminating hepatic
necrosis? - ANS ✓tolcapone


6. Name 2 COMT inhibitors. - ANS ✓entacapone


tolcapone


7. Amantadine antiparkinsonian MOA - ANS ✓increases synthesis,
release or reuptake of dopamine from the surviving neurons


<i>less efficacious than levodopa and tolerance develops more readily, but
fewer side effects


8. Amantadine systemic adverse effects (3/4) - ANS ✓restlessness


agitation


confusion

Psychiatry-Pharmacology (USMLE)

, 3
USMLE



peripheral edema


9. What adverse effect is associated with high doses of
amantadine? - ANS ✓acute toxic psychosis


10. What dermatologic adverse effect is associated with
amantadine? - ANS ✓livedo reticularis


11. Drug of choice for Parkinson's disease - ANS ✓levodopa +
carbidopa


12. Are sedative-hypnotics with linear or non-linear dose-
response relationships dangerous? - ANS ✓linear dose-response
curve


<i>increase in dose above that needed for hypnosis may lead to a state of
general anesthesia


higher doses, they may depress respiratory and vasomotor centers in the
medulla, leading to coma and death


13. What drugs are the most widely used anxiolytic drugs? -
ANS ✓benzodiazepines


14. To what receptors do benzodiazepines bind? - ANS
✓GABA<sub>A</sub> receptors


<i>chloride channels

Psychiatry-Pharmacology (USMLE)

, 4
USMLE



15. List the subunits that make up the pentameric structure of
the GABA<sub>A</sub> receptor. - ANS ✓alpha-2-beta-2-gamma


<i>binding sites located between adjacent alpha and beta subunits


16. Between which 2 subunits of the GABA<sub>A</sub>
receptor does benzodiazepine bind? - ANS ✓alpha subunit


gamma subunit


<i>increased in frequency of channel opening events


17. Which 2 benzodiazepine receptor subtypes are found in
the CNS? - ANS ✓BZ1


BZ2


18. How does benzodiazepine affect the EC50 for the GABA-
induced Cl- influx? - ANS ✓decreases EC50


19. Name a benzodiazepine receptor antagonist. - ANS
✓flumazenil


20. List 3/5 actions of benzodiazepines. - ANS ✓reduction of
anxiety


sedative and hypnotic actions

Psychiatry-Pharmacology (USMLE)

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