,1. Which of the following neurotransmitter systems is primarily
targeted by Selective Serotonin Reuptake Inhibitors (SSRIs)?
A. Dopaminergic
B. GABAergic
C. Noradrenergic
D. Serotonergic
Answer: D. Serotonergic
Rationale: SSRIs function by inhibiting the reuptake of
serotonin (5-HT) in the brain, thereby increasing its availability.
2. What is the primary mechanism of action of atypical
antipsychotics?
A. Inhibition of acetylcholinesterase
B. Dopamine D2 receptor antagonism combined with serotonin
5-HT2A receptor antagonism
C. Inhibition of monoamine oxidase
D. Activation of GABA receptors
, Answer: B. Dopamine D2 receptor antagonism combined
with serotonin 5-HT2A receptor antagonism
Rationale: Atypical antipsychotics target both dopamine and
serotonin receptors to treat symptoms of schizophrenia and other
disorders.
3. Which enzyme is responsible for the metabolism of most
antidepressants in the liver?
A. Monoamine oxidase
B. Catechol-O-methyltransferase
C. Cytochrome P450
D. Acetylcholinesterase
Answer: C. Cytochrome P450
Rationale: The cytochrome P450 enzyme system in the liver
plays a crucial role in the metabolism of many antidepressants.
### Fill-in-the-Blank
4. _________ is a mood stabilizer commonly used in the
treatment of bipolar disorder.
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