Two Directions - correct answer Treat opportunistic infections
Treat HIV infection
Treating Opportunistic Infections - correct answer Better antifungal drugs and
drug regimens
Better antiparasitic drugs and regimens
Treat HIV Infection: Early Days - correct answer AZT: interferes with Reverse
transcriptase, doesn't block cellular polymerase as much, a nuceloside analog
AZT inhibits RNA and DNA polymerases a little bit (like chemo), stop by killing too many of own cells
Looks like what reverse trans will eat, but stops process (sausage)
Single drug means resistance
Experience with AZT - correct answer Side effects
Delays onset of AIDS
Doesn't prolong life
AZT and perinatal transmission - correct answer Reduced mother to newborn
transmission
-no AZT, 24%
-with AZT, 8%
---in US 2% with no breast feeding
Few side effects for fetus
Drug Resistance - correct answer Single drug = resistance
Resistance by mutation is unavoidable
-HIV has major mutation rate
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