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FTM1 drugs exam 1 SGU/SGU SOM FTM 2: Test 2 Diseases study guide
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FTM1 drugs exam 1 SGU/SGU SOM FTM 2: Test 2 Diseases study guide
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FTM1 drugs exam 1 SGU/SGU SOM FTM 2:Test 2 Diseases study guide
Taxol - ANS Anti-cancer drug, Prevent microtubule disassembly
Colchicine - ANS anti-cancer and anti-gout, Prevent microtubule assembly (polymerization)
Fights inflammation
Phalloidin - ANS Disrupt actin function so no cell movement, Inhibit RNA poll II not
absorbed by GI tract not toxic by oral intake
Ciproflaxin - ANS antibiotic, inhibit dna gyrase
novabiocin - ANS antibiotic, inhibit dna gyrase
AZT or zidovudine - ANS Disrupt DNA elongation base lacks 3'OH
Acyclovir - ANS Disrupt DNA elongation base lacks 3'OH
Tenofovir - ANS Disrupt DNA elongation Competes w/ dATP
Didanosine (ddI) - ANS Disrupt DNA elongation base lacks 3'OH
Adenine Arabinoside
(AraA) - ANS 3'OH = stereo restraint chain termination
Cytosine Arabinoside (araC) - ANS anti-cancer, 3'OH = stereo restraint chain termination
Camptothecin - ANS Binds and inhibits topoisomerase I
Etoposide - ANS inhibits topoisomerase II
Actinomycin D - ANS Inhibit RNA pol BOTH prokaryotes + eukaryotes
Rifampin - ANS Inhibit RNA pol inhibit initiation of transcription
⍺-Amanitin
, (mushroom!) - ANS Inhibit RNA pol II hepatotoxicity death
Streptomycin - ANS Blocks initiation: prevents assembly of ribosome by binding to 30s
Tetracycline - ANS Blocks elongation: prevents aminoacyl-tRNA access to A site
Erythromycin - ANS Blocks elongation: blocks ribosome translocation by binding to 50S
Chloramphenicol - ANS Blocks elongation: prevents peptidyl transferase activity in
prokaryotes
Cycloheximide - ANS Blocks elongation: prevents peptidyl transferase activity in eukaryotes
puromycin - ANS Blocks elongation: premature termination in translation by bearing
structural
resemblance to aminoacyl-tRNA
Diphtheria toxin - ANS Inactivates EF-2 prevent translocation (translation??)
Allopurinol - ANS xanthine oxidase inhibitor
Sulfonamide (sulfa drugs) - ANS Inhibit folate synthesis
I Cell disease - ANS -lysosomal storage disorder
-lysosomes lack their normal complement of several enzymes
-many different molecules are not degraded and accumulate forming inclusion bodies
-grouped as mucolipidosis Type II
-transport into lysosomes is defective, lack of phosphorylase to form the mannose 6-P marker,
n-glycosylation itself is normal
Adherence of E. coli - ANS -E. coli attaches to mannose residues that incorporated in the
plasma membrane of human cheek cells
-first step in bacterial infection
Adherence of Helicobacter pylori - ANS -helicobacter pylori attached to the gastric surface
-bacterium leads to ulcers by interaction with a specific blood group antigen of the gastric
epithelium
Hypoxia - ANS -reduction in normal level of oxygen tension
-occurs during several pathophysiological processes including tumorigenesis
-HIF-1 activity (HIF1alpha and HIF1beta)
Osteogenesis Imperfecta - ANS -brittle bones
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