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ASCP CGMBS Exam Study Questions and Complete Solutions Graded A+ $14.49   Add to cart

Exam (elaborations)

ASCP CGMBS Exam Study Questions and Complete Solutions Graded A+

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  • Course
  • ASCP CG
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  • ASCP CG

ASCP CGMBS Exam Study Questions and Complete Solutions Graded A+

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  • August 22, 2024
  • 8
  • 2024/2025
  • Exam (elaborations)
  • Questions & answers
  • ASCP CG
  • ASCP CG
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ASCP CGMBS Exam
Study Questions
and Complete
Solutions Graded
A+
Denning [Date] [Course title]

, BCR;ABL1 fusion protein - Answer: t(9;22)(q34;q11)



Acute Promyelocytic Leukemia (APL) - Answer: t(15;17) a fusion of PML and RARA



Burkitt's Lymphoma - Answer: t(8;14) the breakpoints on chr.8 are spread of 190 kbp region 5' to and
within the C-MY C gene



Follicular Cell Lymphoma (FCL) - Answer: t(14;18) translocation disregulate BCL2, which inhibits
apoptosis in B lymphocytes, which leads to survival of genetically damaged cells



Mantle Cell (MCL) - Answer: t(11;14) translocation increases expression of CCND1



Chronic Myelogenous Leukemia (CML) - Answer: t(9;22) aka Philadelphia Chromosome, translocation
occurs within two genes: the breakpoint cluster region (BCR) on chr.22 and the cellular counter part of
the Abelson Leukemia virus tyrosine kinase (c-abl) on chr.9



Marginal Zone Lymphoma - Answer: t(11;18)



Vorinostat/Zolina - Answer: second-line drug for cutaneous T-cell lymphoma. Treatments are often
used in combination with phototherapy and chemotherapy



Irinotecan - Answer: UGT1A1 - Prevents DNA from unwinding by inhibition of topoisomerase 1



Warfarin (Coumadin) - Answer: CYP2C9 and VKORC1 - Vitamin K antagonist; metabolized primarily via
oxidation in the liver by CYP2C9 and exerts its anticoagulant effect by inhibiting the protein vitamin
epoxide reductase complex, subunit 1 (VKORC1)



Tamoxifen - Answer: CYP2D6 - anti estrogen therapy for hormone receptor-positive breast cancer in
pre-menopausal women



Azathioprine - Answer: TPMT - immunosuppresive used in organ transplant

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