Exam (elaborations)
ASCP CGMBS Exam Study Questions and Complete Solutions Graded A+
- Course
- Institution
ASCP CGMBS Exam Study Questions and Complete Solutions Graded A+
[Show more]
Content preview
ASCP CGMBS ExamStudy Questions
and Complete
Solutions Graded
A+
Denning [Date] [Course title]
, BCR;ABL1 fusion protein - Answer: t(9;22)(q34;q11)
Acute Promyelocytic Leukemia (APL) - Answer: t(15;17) a fusion of PML and RARA
Burkitt's Lymphoma - Answer: t(8;14) the breakpoints on chr.8 are spread of 190 kbp region 5' to and
within the C-MY C gene
Follicular Cell Lymphoma (FCL) - Answer: t(14;18) translocation disregulate BCL2, which inhibits
apoptosis in B lymphocytes, which leads to survival of genetically damaged cells
Mantle Cell (MCL) - Answer: t(11;14) translocation increases expression of CCND1
Chronic Myelogenous Leukemia (CML) - Answer: t(9;22) aka Philadelphia Chromosome, translocation
occurs within two genes: the breakpoint cluster region (BCR) on chr.22 and the cellular counter part of
the Abelson Leukemia virus tyrosine kinase (c-abl) on chr.9
Marginal Zone Lymphoma - Answer: t(11;18)
Vorinostat/Zolina - Answer: second-line drug for cutaneous T-cell lymphoma. Treatments are often
used in combination with phototherapy and chemotherapy
Irinotecan - Answer: UGT1A1 - Prevents DNA from unwinding by inhibition of topoisomerase 1
Warfarin (Coumadin) - Answer: CYP2C9 and VKORC1 - Vitamin K antagonist; metabolized primarily via
oxidation in the liver by CYP2C9 and exerts its anticoagulant effect by inhibiting the protein vitamin
epoxide reductase complex, subunit 1 (VKORC1)
Tamoxifen - Answer: CYP2D6 - anti estrogen therapy for hormone receptor-positive breast cancer in
pre-menopausal women
Azathioprine - Answer: TPMT - immunosuppresive used in organ transplant
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller YourExamplug. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $14.49. You're not tied to anything after your purchase.
Can Stuvia be trusted?
4.6 stars on Google & Trustpilot (+1000 reviews)
81989 documents were sold in the last 30 days
Founded in 2010, the go-to place to buy study notes for 14 years now