Exam (elaborations)
PHM 450 - Final Exam Questions With Complete Solutions
- Course
- PHM 450
- Institution
- Florida State University
PHM 450 - Final Exam Questions With Complete Solutions
[Show more]
Content preview
PHM 450 - Final Exam Questions With Complete Solutions______________ are a type of columnar epithelial cell lined
with cilia that are found in the conducting portion of the airway.
Correct Answers goblet cells
______________ is a condition characterized by accumulation
of lipid-containing masses (known as plaques) that form in the
lumen of blood vessels. Correct Answers Atherosclerosis
_______________ irreversibly inhibits the mitochondrial
respiratory chain at cytochrome aa3, resulting in loss of ATP
production and rapid cell death. Correct Answers cyanide
A 2013 study demonstrated that mice can pass on certain fears
to their offspring, and that responses to these fearful stimuli lasts
at least two generations. The surprising aspect of this inheritance
was that it takes place without any DNA alterations. This type of
inheritance is classified as: Correct Answers epigenetic
A chemical carcinogen that requires metabolic activation to
become carcinogenic is known as a(n): Correct Answers
procarcinogen
A common cause of spontaneous point mutations is the
deamination of cytosine to: Correct Answers Uracil
A compound that is altered to become more hydrophilic, larger,
and carrying a charge will make the compound: Correct
Answers easier to excrete from the body
,A drug company is developing a new chemical compound to
treat metastatic brain cancer. As part of the pre-clinical in vitro
assessment, the drug is tested for potential liver toxicity in
humans. The company has a very limited amount of compound
with which to perform the studies. Which of the following
model systems is best suited to these experiments? Correct
Answers Human hepatocytes in primary culture
A group of cardiac myocytes connected together by intercalated
discs is called a(n): Correct Answers syncytia
A highly lipophilic toxicant would be expected to be stored in:
Correct Answers adipose tissue
A New Drug Application (NDA) is filed after Phase ____
clinical trials. Correct Answers III
A particle with a diameter of 1 micron or smaller will be
deposited in which part of the lung? Correct Answers alveoli
A person breathes in small bacteria that settle in the lungs.
Which type of cell would you expect to attack the bacteria and
clean up the resulting debris? Correct Answers Macrophages
A rat is treated with Chemical X via IP injection for 7 days.
After 7 days, the liver is removed and analyzed for adverse
effects. This is an example of an: Correct Answers in vivo
experiment
A sustained elevation of intracellular ____________ is usually
an initiating step in cell death. Correct Answers Calcium
, A toxic substance produced by a biological organism is
generally known as a: Correct Answers toxin
Acetaminophen is metabolized by the following Phase I
enzyme: Correct Answers CYP2E1
Acetaminophen metabolism switches to the secondary, more
toxic metabolism pathway once: Correct Answers Glutathione
is depleted
Acute alcohol (ethanol) overdose has the following cardiac
effect: Correct Answers
acute renal failure can be reversible. Correct Answers true
Acute toxicity studies are important because they: Correct
Answers identify target organs, identify sensitive species, serve
as dose-range finding studies, determine the LD50
All of the following statements regarding biotransformation are
true EXCEPT: Correct Answers Biotransformation causes a
large increase in hydrophilicity
All of the following statements regarding cytochrome P450 are
true EXCEPT: Correct Answers Increased activity of CYP450
typically slows the rate of xenobiotic activation.
All of the following statements regarding lead exposure are true
EXCEPT: Correct Answers Lead interferes with acetylcholine
release at nerve terminals
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller Classroom. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $14.99. You're not tied to anything after your purchase.
Can Stuvia be trusted?
4.6 stars on Google & Trustpilot (+1000 reviews)
78252 documents were sold in the last 30 days
Founded in 2010, the go-to place to buy study notes for 14 years now