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Lipscomb Biochemistry Final Exam Review 2024/2025 Questions With Completed & Verified Solutions.
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Lipscomb Biochemistry Final Exam Review 2024/2025 Questions With Completed & Verified Solutions.
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Lipscomb Biochemistry Final ExamReview
Proteins with two different polypeptide chains are: - ANS heterodimeric proteins
A common reaction of two cysteine residues in proteins results in the formation of - ANS a
disulfide bond
Reaction of the peptide ala-met-lys-ser with phenylisothiocyanate at pH 8.0 followed by mild
acidification would release: - ANS PTH-ser and the peptide ala-met-lys
The hydrophobic R groups found in globular proteins are nearly always located: - ANS in the
interior of the protein
The term used to refer to how indicivual polypeptide chains of a protein having 2 or more chains
are arranged in relation to each other is: - ANS quaternary structure
The alpha helical structure found in many proteins is stabilized primarily by: - ANS hydrogen
bonds
The observation that some proteins are coiled like a helix refers to which structure of a protein?
- ANS secondary structure
If a rapidly exercising muscle suffers a lack of oxygen it will accumulate: - ANS Lactate
Enzymes have active sites which have the greatest complementarity to the: - ANS The
substrate
In the calalytic triad common to many serine proteases, _____ increases the basicity of _____,
thus allowing deprotonation of ____ to serve as a nucleophile. - ANS Asp-His-Ser
In an anaerobic organism, glycolysis is followed immediately by: - ANS Fermentation
An alcoholic went on a weekend binge. The catabolism of ethyl alcohol yields NADH, mainly in
the liver. So, as a result of high NADH levels, pyruvate would be converted into: - ANS Lactate
The pentose phosphate pathway generates: - ANS ribose-5-phosphate
Which of the following is the major advantage of a multi-enzyme complex? - ANS Multi-enzyme
complexes are much less likely to be inhibited.
, Which of the following will cause an increase in the activity of glycogen phosphorylase? - ANS
Phosphorylation of the enzyme.
The pentose phosphate pathway is an important source of ____, and for ____, an essential
precursor for ATP, NAD+, CoA, DNA, and RNA. - ANS NADPH; ribose-5-phosphate
What is the purpose of phosphorylation in glycolysis? How is it accomplished? What does this
mean for glycolytic intermediates inside the cell? - ANS Phosphorylation traps glucose inside
the cell in order to proceed. ATP provides the phosphate and is reduced to ADP as a result. This
means that the reaction has no choice but to go forward.
In glycolysis, the conversion of dihydroxyacetone phosphate to glyceraldehyde-3-phosphate,
catalyzed by the triosephosphate isomerase, is reversible. Given that the equilibrium the
reaction strongly favors the formation of dihydroxyacetone phosphate, how does glycolysis
proceed? - ANS The delta G is highly positive so this serves as a check point to prevent
synthesis of unneeded products and will only proceed if lots of Fructose-1,6-bisphosphate builds
up.
What are the advantages of compartmentalizing particular metabolic pathways within specific
organelles? For instance, fatty acid oxidation occurs in the mitochondrion, while fatty acid
synthesis occurs in the cytoplasm. What are the advantages of this arrangement? - ANS This
gives the reaction a set space to ensure the reactive interactions will occur. Surface markers are
also essential for certain reactions and chemical concentrations must be exact. This also
ensures the reactants of one cycle does not interfere with another.
Why is it more sensible for phosphofructokinase to be an important control step, rather than
hexokinase? - ANS Phosphofructokinase catalyzes the first committed step to glycolysis, but the
glucose-6-phosphate step can lead to many other pathways possibly.
When the pH for a solution of a weak acid is equal to the pKa, the ratio of the concentration of
the salt and the acid ([A-]/[HA]) is: - ANS 1
The carboxyl terminal (C-terminal) amino acid of the hexapeptide asp-ala-ser-glu-val-arg is: -
ANS Asparagine
Of the 20 standard amino acids, only _____ is R. The reason is that its side chain _______. -
ANS Cysteine, contains an S bonded to the beta carbon.
Which of the following is produced from two amino acids by an oxidation reaction? - ANS
Phenylalanine
In a comparison of similar proteins in different organisms, what would constitute a conservative
substitution instead of exact homology? - ANS A similar amino acid being replaced like leucine
to isoleucine.
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