100% satisfaction guarantee Immediately available after payment Both online and in PDF No strings attached
logo-home
Previously searched by you
Previously searched by you
logo
Antiphospholipid antibodies and cerebrovascular thrombosis in the pediatric population: Few answers to many questions $16.49
Add to cart
Quickly navigate to
Preview
  2.  
  3. Antiphospholipid Antibodies And Cerebrovascular
  4.  
  5. Antiphospholipid antibodies and cerebrovascular

Exam (elaborations)

Antiphospholipid antibodies and cerebrovascular thrombosis in the pediatric population: Few answers to many questions
 0 purchase
  • Course
  • Antiphospholipid antibodies and cerebrovascular
  • Institution
  • Antiphospholipid Antibodies And Cerebrovascular

2. Antiphospholipid antibodies and cerebral thrombosis 2.1. Lupus anticoagulant In neonates and children, LAC are sometimes found incidentally due to prolongation of activated partial thromboplastin time (20). As LAC can be transient and associated with infections and transplacental passage (...

[Show more]

Preview 3 out of 25  pages

Document information

  • August 24, 2024
  • 25
  • 2024/2025
  • Exam (elaborations)
  • Questions & answers

Subjects

  • antiphospholipid antibodies and cerebrovascular th
  • antiphospholipid antibodies and cerebral thrombo
  • 212 neonatal sinovenous thrombosis

Written for

  • Antiphospholipid antibodies and cerebrovascular
  • Antiphospholipid antibodies and cerebrovascular

Seller

avatar-seller
StudyCenter1

Reviews received

Content preview

AperTO - Archivio Istituzionale Open Access dell'Università di Torino




Antiphospholipid antibodies and cerebrovascular thrombosis in the pediatric population: Few
answers to many questions

This is the author's manuscript

Original Citation:




Availability:

This version is available http://hdl.handle.net/2318/1795807 since 2021-08-04T11:59:06Z




Published version:

DOI:10.1177/09612033211021488

Terms of use:

Open Access
Anyone can freely access the full text of works made available as "Open Access". Works made available
under a Creative Commons license can be used according to the terms and conditions of said license. Use
of all other works requires consent of the right holder (author or publisher) if not exempted from copyright
protection by the applicable law.




(Article begins on next page)




10 December 2023

,Title
Antiphospholipid antibodies and cerebrovascular thrombosis in the pediatric population: Few answers to
many questions




1

, Abstract
Most of the knowledge in pediatric antiphospholipid syndrome (APS) is derived from studies
performed on the adult population. As in adults, antiphospholipid antibodies (aPL) can contribute to
thrombosis, especially cerebrovascular thrombosis, in neonates and children. Since aPL have the
potential to cross the placental barrier, and since the pediatric population is prone to infections,
confirmation tests are required to specify a role for aPL in cerebrovascular thrombosis. In this review, we
aimed at assessing the prevalence of aPL, criteria or non-criteria, in neonatal and childhood ischemic
stroke and sinovenous thrombosis. Also, we looked into the effect of aPL and anticoagulants/antiplatelets
on the long term neurological outcomes of affected neonates or children. While most questions remained
un-answered because of the very limited evidence, the neurological outcomes seem to be affected by the
titers of aPL at the time of the event and subsequent confirmatory tests. In the settings of pediatric
population, anti-beta-2 glycoprotein I antibodies (anti-β2GPI) antibodies have been associated with
unusual arterial locations. Long term administration of aspirin has been safe, even though neurological
complications have been noted. Anticoagulation with low-molecular-weight heparin (LMWH) or vitamin K
antagonists, especially in combination with aspirin, has shown favorable outcomes in few cases.
However, the limited amount of data requires caution when interpreting the available evidence, especially
when referring to the most optimal choice of anticoagulation.
Keywords: Antiphospholipid antibodies; pediatric population; cerebrovascular thrombosis; anticoagulation




2

The benefits of buying summaries with Stuvia:

Guaranteed quality through customer reviews

Guaranteed quality through customer reviews

Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.

Quick and easy check-out

Quick and easy check-out

You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.

Focus on what matters

Focus on what matters

Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!

Frequently asked questions

What do I get when I buy this document?

You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.

Satisfaction guarantee: how does it work?

Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.

Who am I buying these notes from?

Stuvia is a marketplace, so you are not buying this document from us, but from seller StudyCenter1. Stuvia facilitates payment to the seller.

Will I be stuck with a subscription?

No, you only buy these notes for $16.49. You're not tied to anything after your purchase.

Can Stuvia be trusted?

4.6 stars on Google & Trustpilot (+1000 reviews)

68175 documents were sold in the last 30 days

Founded in 2010, the go-to place to buy study notes for 15 years now

Start selling
$16.49
  • (0)
Add to cart
Added