MS is a _____________ disorder that is brought on by both genetic and environmental
factors. - ANSdemyelinating
BOX 8-1: MULTIPLE SCLEROSIS
MS is an _________ disorder that is believed to involve both genetic and environmental
factors
Environmental factors that increase the risk for MS
- infection w/ the Epstein-Barr virus
- deficiency of Vit D - ANSautoimmune
BOX 8-1: MULTIPLE SCLEROSIS
In MS, the autoantibodies that are produced destroy the _____________ , the
myelin-producing neuroglia of the CNS, which results in the formation of scleroses, or
plaques of scar tissue, that do not provide electrical insulation or protect the axon
Bc loss of myelin may occur in many parts of the CNS, the symptoms vary, but usually
include:
- muscle weakness or paralysis
- numbness or partial loss of sensation
- double vision
- loss of spinal cord reflexes, including urination and defecation - ANSoligodendrocytes
BOX 8-1: MULTIPLE SCLEROSIS
The first sxs usually appear between the ages of ___ and ____ yrs
- remissions and progression of the disease are not predictable
- there is no cure for MS - ANS20 and 40
TABLE 8-1: NEUROGLIA
OLIGODENDROCYTES
- produce the segments of the myelin sheath to electrically insulate neurons of the CNS
MICROGLIA
- capable of movement and phagocytosis of pathogens and damaged tissue
, ASTROCYTES
- provide a framework for the developing fetal brain and support established neurons
- regulate localized blood flow in response to brain activity
- help maintain K+ level
- contribute to the blood-brain barrier
EPENDYMA
- line the ventricles of the brain and central canal of the spinal cord; many of the cells have
cilia; involved in circulation of cerebrospinal fluid - ANS
TABLE 8-2: THE NERVE IMPULSE
POLARIZATION (the neuron is not carrying an electrical impulse)
- neuron membrane has a positive (+) charge outside and a negative (-) charge inside
- Na+ ions are more abundant outside the cell
- K+ ions and negative ions are more abundant inside the cell. Sodium and potassium
pumps maintain these iron concentrations - ANS
TABLE 8-2: THE NERVE IMPULSE
DEPOLARIZATION (generated by a stimulus)
- neuron membrane becomes very permeable to Na+ ions, which rush into the cell
- the neuron membrane then has a negative (-) charge outside and a positive (+) charge
inside - ANS
TABLE 8-2: THE NERVE IMPULSE
PROPAGATION OF THE IMPULSE FROM POINT OF STIMULUS
- depolarization of part of the membrane makes adjacent membrane very permeable to Na+
ions, and subsequent depolarization, which similarly affects the next part of the membrane,
and so on
- the depolarization continues along the membrane of the neuron to the end of the axon -
ANS
TABLE 8-2: THE NERVE IMPULSE
REPOLARIZATION (immediately follows depolarization to complete the action potential)
- neuron membrane becomes very permeable to K+ ions, which rush out of the cell. This
restores the positive (+) charge outside and negative (-) charge inside the membrane
- the Na+ ions are returned outside and the K+ ions are returned inside by the sodium and
potassium pumps
- the neuron is now able to respond to another stimulus and generate another impulse - ANS
TABLE 8-3: MAJOR PERIPHERAL NERVES
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