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FPGEE TEST QUESTIONS AND ANSWERS
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FPGEE TEST QUESTIONS AND ANSWERS
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FPGEE TEST QUESTIONS AND ANSWERSThe 2016 CDC guideline for prescribing opioids suggests to reassess the evidence of
"individual benefit and risk" when increasing daily dose to above ____ morphine
milligrams equivalent per day.
The 2016 CDC guideline for prescribing opioids suggests to reassess the evidence of
“individual benefit and risk” when increasing daily dose to above 50 morphine milligrams
equivalent per day, and avoidance of doses greater than 90 MME per day.
A decrease in renal and liver function, as seen in the elderly, would prolong drug half-
life,_____________ plasma protein binding, and _____________volume of distribution.
decrease
decrease
Which of the following are the two modifying factors that contribute to why women have
higher blood peak concentrations of alcohol than men when consuming equivalent
amounts?
women have higher fat content and less gastric alcohol dehydrogenase (ADH)
what is the minimal effective concentration (MEC)?
the minimal drug plasma concentration to produce effect
Fick's Law of Diffusion
diffusion through a membrane is directly proportional to the surface area and
concentration gradient and inversely proportional to the thickness of the membrane and
its resistance
acid-base reaction
reaction involving the transfer of a hydrogen ion between reactant species
how to distinguish acids from bases:
-bases usually have OH and are bonded to a nonmetal
-acids usually bonded to metals and have a positive charge
Arrhenius acid
,Produces H+ ions when dissolved in water
(proton donors)
strong acids ionize completely
weak acids dont ionize completely
the most common strong acids are:
hcl
hbr
HI
HNO3 (nitric acid)
H2SO4
HClO4
weak acids:
HF
NH4+
Hc2H3O2 (acetic acid)
HCN
HNO2 (nitrous acid)
H2SO3
when dealing with oxy-acids, the acid that has more oxygen atoms will be the more
acidic one
LEWIS acids are electron acceptors
Arrhenius base
Produces OH- ions when dissolved in water
(proton acceptors)
strong bases: (soluble- form strong electrolytes)
KOH
NaOH
Ba(OH)2
weak bases:
,Al(OH)3 -insoluble thus do not ionize well
NH3
F-
NO2-
C2H3O2-
LEWIS bases are electron donors
The principle of drug manipulation for excretion of a drug out of the renal tubule can be
accomplished by
Adjusting the urinary pH to ionize the drug
binding to plasma proteins
acidic drugs such as phenytoin bind to ALBUMIN
basic drugs such as lidocaine bind primarily to alpha1-acid glycoprotein(AAG)
bioavailability of a drug
is the amount of a drug absorbed per amount administered
for a generic drug to be bioeqivalent it must be measured in ____ of subjects to fall
within ____ of the mean of the test population bioavailability
(PER FDA)
80
20
Using the FDA bioequivalence rule, how much variation could a generic drug potentially
have from an innovator and still be considered equivalent?
40%
how much of oral morphine is metabolized on its first pass through the liver
90%
ATSDR
Agency for Toxic Substances and Disease Registry; one of the DHHS Operating
Divisions.
DHHS (Department of Health and Human Services)
The national agency that deals with health in the United States.
SAMHSA
, Substance Abuse and Mental Health Administration; coordinates and funds sustainable
substance abuse and mental health programs in communities or community health
agencies
CBER
The center for biological evaluation and research (CBER) ensures the safety and
efficacy o f blood products , vaccines, allergenics, biological therapeutics, somatic cell
therapy, gene therapy, and banked human tissue.
The center for food safety and applied Nutrition (CFSAN) established the CFSAN
adverse events reporting systems ( CAERS) in 2002 to identify potentially serious
problems secondary to the non-FDA approved herbs, minerals, vitamins, dietary
supplements, and other substances.
87. Which of the following are administered by Centers for Medicare & Medicaid
Services (CMS)? [Select ALL That Apply] a. Medicare
b. Medicaid
c. Clinical Laboratory Improvement Amendments (CLIA)
d. Children's Health Insurance Program (CHIP)
ALL
Answer (a, b, c and d). The Centers for Medicare & Medicaid Services (CMS), a
component of the Department of Health and Human Services (HHS), administers
Medicare, Medicaid, the Children's Health Insurance Program (CHIP), the Clinical
Laboratory Improvement Amendments (CLIA) and parts of the Affordable Care Act
(ACA.
86. Which of the following information is/are TRUE ABOUT Essential Fatty Acids?
[Select ALL That Apply]
a. Linoleic and alpha-linolenic are essential fatty acids.
b. Arachidonic acid is classified as ‘conditionally essential’ fatty acid.
c. Ideally, in the diet, the ratio of omega-6 to omega-3 fatty acids should be between 1:1
and 4:1.
d. Excessive intake of omega-6 fatty acids can cause the deficiency of omega-3 fatty
acids.
ALL
Answer (a, b, c and d). Essential fatty acids, or EFAs, are fatty acids that humans and
other animals must ingest because the body requires them for good health but cannot
synthesize them.
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