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Tricyclic Antidepressants | Questions And Answers Latest {} A+ Graded | 100% Verified
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Tricyclic Antidepressants | Questions And Answers Latest {2024- 2025} A+ Graded | 100%Verified
What neurotransmitters do TCAs inhibit reuptake of into the presynaptic neuron? - Norepinephrine and
serotonin.
If discovered today, what class of antidepressants might TCAs have been referred to as? - SNRIs
(Serotonin-Norepinephrine Reuptake Inhibitors).
What distinguishes TCAs from SNRIs despite their similar mechanism of action? - TCAs have different
adverse effects relative to SNRIs.
Name the tertiary amine that serves as the prototype drug for TCAs. - Imipramine
Which TCAs are classified as secondary amines? - Desipramine and nortriptyline.
What are the N-demethylated metabolites of imipramine and amitriptyline, respectively? - Desipramine
(of imipramine) and nortriptyline (of amitriptyline).
Name two related "tetracyclic" antidepressant agents that are commonly included in the general class of
TCAs. - Maprotiline and amoxapine.
What neurotransmitter reuptake do TCAs and amoxapine inhibit? - Norepinephrine and serotonin.
Besides TCAs, which specific agents are relatively selective inhibitors of norepinephrine reuptake? -
Maprotiline and desipramine.
Apart from inhibiting neurotransmitter reuptake, what other receptors do TCAs block? - Serotonergic, α-
adrenergic, histaminic, and muscarinic receptors.
What is likely responsible for many of the adverse effects of TCAs? - Actions at serotonergic, α-
adrenergic, histaminic, and muscarinic receptors.
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