Face valid models they're going to measure what they're supposed to
Inference models use behavioral or biological response to infer processes related to humans
What are the scientific guidelines of animal research? 1. Quality of research must be dependent on care, health, well-being, ethical trea...
BBH 311 Exam 2 Review Questions and
Correct Answers
Face valid models ✅they're going to measure what they're supposed to
Inference models ✅use behavioral or biological response to infer processes related to
humans
What are the scientific guidelines of animal research? ✅1. Quality of research must be
dependent on care, health, well-being, ethical treatment of animals
2. Follow laws + regulations at state, federal, institutional, community levels
3. Scientists must be trained in guidelines
What does penn state office for research protections do? ✅- ensure extensive training
of personnel
- research application review
Professional, community, and governmental levels of review include what aspects?
✅1. Justification of research
2. Personnel
3. Care & housing
4. Acquisition of animals
5. Experimental procedures
6. Field research
7. Educational use of animals, consider other models if possible
What are the three r's regarding human research? ✅1. Replace (may use a non animal
alternative)
2. Reduce (the # of animals used/effected)
3. Refine (less pain + distress)
What kind of research animals do we use? ✅- mice/rats majority (have biological
similarities to humans)
- may include rabbits/farm animals
- fruit flies/worms for genetic research
Mechanistic models ✅high specialization
rigid departmentalization
clear chain of command
narrows spans of control
, centralization
high formalization
What are some potential alternatives for animal research? ✅- many times, there is not
one
- may use test tube (in vitro), human cells/tissues, computer models, non-invasive
imaging
Aim of alzoubi ? ✅examine the effect of ptx drug on ptsd induced memory impairment
in rat model
Hypothesis of alzoubi ✅1. Ptx would have protective effect on learning ability +
memory functions in a rat model with ptsd behaviors
2. Ptx would modulate biomarkers of oxidative stress, bdnf, histones
What effect does stress exposure have on oxidative stress? ✅increases it
How does oxidative stress effect us? ✅alters neuronal integrity
What does brain-derived neurotropic factor (bdnf) do? ✅supports neuronal health, impt
in plasticity, learning, memory, higher thinking
What are hippocampal histones used for? ✅plasticity, long term memory, neuronal
health
What were the independent variables in alzoubi study? ✅1. Drug (ptx or placebo)
2. Stress (sps or no stress)
What were the 4 groups used in alzoubi study? ✅1) control - no drug, no stress
2) sps - stress, no drug
3) ptx - no stress, drug
4) ptx + stress
What methods were used in regards to drugs in the alzoubi study? ✅control rats
received saline
Experimental rats received 100mg/kg of ptx, 6 days a week for 4 weeks
What methods were used in regards to stress in alzoubi study? ✅- sps and ptx/sps got
sps one week after ptx admin
- sps with saline injection
What memory test was used in alzoubi study? ✅radial arm water maze
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