Cardio - Antiarrhythmic Drugs UPDATED Exam Questions and CORRECT Answers
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Cardio - Antiarrhythmic Drugs
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Cardio - Antiarrhythmic Drugs
Cardio - Antiarrhythmic Drugs UPDATED
Exam Questions and CORRECT Answers
What do class 1 antiarrythmics affect? - Correct Answer- Fast Na channels
What do class 2 antiarrhythmics affect? - Correct Answer- beta blockers
What to class 3 antiarrhythmics affect? - Correct Answer- block K channels
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Cardio - Antiarrhythmic Drugs UPDATED
Exam Questions and CORRECT Answers
What do class 1 antiarrythmics affect? - Correct Answer- Fast Na channels
What do class 2 antiarrhythmics affect? - Correct Answer- beta blockers
What to class 3 antiarrhythmics affect? - Correct Answer- block K channels
What do class 4 antiarrhythmics affect? - Correct Answer- calcium channel blockers
Which drugs are class 1a? - Correct Answer- quinidine, procainamide, disopyramide
How does class 1a work? - Correct Answer- slow the rate of rise of the action potential and
prolong its duration, thus slowing conduction and increasing refractoriness (moderate
depression of phase 0 upstroke of the action potential)
Which drugs are class 1b? - Correct Answer- lidocaine, mexiletine
How does class 1b work? - Correct Answer- shorten action potential duration; they do not
affect conduction or refractoriness (minimal depression of phase 0 upstroke of the action
potential)
Which drugs are class 1c? - Correct Answer- flecainide, propafenone
How does class 1c work? - Correct Answer- prolong rise of the action potential and slow
repolarization, thus slowing conduction, but more so than class Ia drugs (maximal depression
of phase 0 upstroke of the action potential)
Quinidine - Correct Answer- Has potent anticholinergic properties that affect the SA and AV
nodes, which can increase the SA nodal discharge rate and AV nodal conduction
This may lead to increased ventricular rates with afib or aflutter
, Addition of a beta blocker, non-dihydropyridine CCB, or digoxin protects against this
Common adverse effects are GI-related - N/V/D
Proarrhythmic - torsades
Can interact with CYP3A4 inducers or inhibitors
Procainamide - Correct Answer- Does not have the anticholinergic activity of quinidine
Prolongs the QT interval, therefore increases risk of torsades
Adverse effects:
Development of a clinical syndrome similar to SLE - most common adverse event
N/V/D and drug fever
Disopyramide (Norpace) - Correct Answer- Potent anticholinergic and negative inotropic
effects limits uses clinically
Prolongs QT, increasing risk of torsades
Contraindicated in patients with reduced LV EF (<40%)
Adverse events:
Precipitation of CHF
Anticholinergic effects - dry mouth, urinary retention, constipation, blurred vision
Lidocaine - Correct Answer- Selective to ischemic tissue, and especially to active fast sodium
channels in the bundle of HIS, Purkinje fibers, and ventricular myocardium
Little effect on non-ischemic tissue, the atrial myocardium, and the automaticity of the SA
node
Primarily effective in treating ventricular dysrhythmias, especially those associated with
acute MI
Cleared by hepatic metabolism, therefore, monitor closely for signs of toxicity in patients
with liver failure
Adverse events:
CNS effects of dizziness, paresthesia, disorientation, tremor, agitation, seizures and
respiratory arrest
Mexiletine - Correct Answer- Similar to lidocaine, but in oral form
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