Antipsychotics NURS 752
Concept of 1st Gen binding thresholds - ANS The degree of D2 receptor binding in the
mesolimbic system is close to 80% to have best effects for relieving psychosis. PROBLEM - 1st
gen don't discriminate and block D2 receptors everywhere in the brain. When D2 increases over
80% in the dorsal striatum EPS effects occur and in the pituitary hyperprolactinemia occur.
Three main features of neurolepsis include: - ANS Psychomotor slowing, emotional quieting
and affective indifference.
Positive symptoms include: - ANS Delusions, Hallucinations and Thought Disorder.
Negative symptoms include: - ANS •Loss or diminution of normal function
•Lack•Loss or diminution of normal function
•Lack of motivation
•Poverty of speech
•Blunted affect
•Poor self-care
•Social withdrawal of motivation
Overactivity or Underactivity of the mesocortical dopamine system mediate the negative,
cognitive, and affective symptoms of schizophrenia? - ANS Underactivity
Cognitive symptoms include: - ANS •Disordered thinking
•Reduced ability to focus attention
•Prominent learning and memory difficulties
•Subtle changes may appear years before symptoms become florid
•Florid changes: Thinking and speech may be completely incomprehensible to others
Which drugs reverse the effects of Parkinsonism? - ANS •diphenhydramine, trihexyphenidyl,
and benztropine.
What is the first drug approved for Tardive Dyskinesia? - ANS Valbenazine (Ingrezza)
symptoms of neuroleptic malignant syndrome - ANS •Lead pipe" rigidity, sudden high fever,
sweating, autonomic instability, dysrhythmias, fluctuations in blood pressure, altered level of
consciousness, and seizures or coma may develop
•Death can result from respiratory failure, cardiovascular collapse, dysrhythmias, and other
causes
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