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Midterm Exam: NR565 / NR 565 (Latest Update 2024 / 2025) Advanced Pharmacology Fundamentals | Review Study Guide | 100% Correct | Grade A - Chamberlain $7.99
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Midterm Exam: NR565 / NR 565 (Latest Update 2024 / 2025) Advanced Pharmacology Fundamentals | Review Study Guide | 100% Correct | Grade A - Chamberlain
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Midterm Exam: NR565 / NR 565 (Latest Update 2024 / 2025) Advanced Pharmacology Fundamentals | Review Study Guide | 100% Correct | Grade A - Chamberlain Question: Beer's Criteria Answer: Includes five lists that describe certain medications and situations that include potentially inappropr...

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  • August 28, 2024
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Midterm Exam: NR565 / NR 565
(Latest Update )
Advanced Pharmacology
Fundamentals | Review Study
Guide | 100% Correct | Grade A -
Chamberlain


Question:
Beer's Criteria
Answer:
Includes five lists that describe certain medications and situations that
include potentially inappropriate medication (PIM) use in older adults.


PIM d/t medication-disease or medication-syndrome to be used cautiously in
older adults


Medications to be avoided or dosage, decreased in the presence of impaired
kidney function in older adults

,Question:
Why do nitrates need to be taken no later than 4 PM?
Answer:
Need nitrate free interval so tolerance doesn't develop




Question:
Cytochrome P450 (CYP450)
Answer:
A class of liver enzyme system where many medication's are metabolized.


•metabolization can be inhibited or induced by drugs, and once this happens,
drug - drug interactions can occur.




Question:
CYP450 inhibitors
Answer:
Prevent (decrease) the CYP450 enzymes from working or reduce the rate of an
enzyme - catalyzed reaction.


Inhibitors block the metabolic activity of one or more CYP450 enzymes.


Result in an increase the concentration of the drug.

,Question:
Examples of CYP450 inhibitors (slideshow)
Answer:
SICKFACES.COM


Sodium Valproate
Isoniazid
Cimetidine
Ketoconazole
Fluconazole
Alcohol (acute/binge)
Ciprofloxacin; Chloramphenicol
Erythromycin
Sulfonimides
Cranberry juice/Grapefruit juice
Omeprazole
Metronidazole




Question:
CYP450 inducers
Answer:
These enzymes speed up the metabolism of drugs and decrease the blood
levels

, Question:
What do CYP450 inhibitors do if they are not used correctly? What could the
patient experience?
Answer:
Severe toxicity can result if the CYP450 enzyme-inhibiting drugs are added to
the following medication: atypical antipsychotics, benzodiazepines,
cyclosporine, statins, or warfarin.




Question:
Examples of CYP450 inducers
Answer:
BS CRAP GPS


Barbituates
St Johns Wort


Carbamazepine
Rifampin
Alcohol (chronic)
Phenytoin


Griseofulvin
Phenobarbital
Sulfonylureas

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