NUR 426 Exam 2 Sirs & Mods Questions and Correct Answers
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Course
NUR 426
Institution
NUR 426
*Response to something- remote response- the body is overly dramatic- Generalized inflammation- at a cellular level- you cannot see it- cellular damage from inflammation-
-infection (sepsis) -ischemia -infarction -injury Causes of SIRS
*sepsis -microbial invasion (bacteria, viruses, fungi, parasi...
NUR 426 Exam 2 Sirs & Mods Questions
and Correct Answers
*Response to something- remote response- the body is overly dramatic- Generalized
inflammation- at a cellular level- you cannot see it- cellular damage from inflammation-
-infection (sepsis)
-ischemia
-infarction
-injury ✅Causes of SIRS
*MECHANICAL TISSUE TRAUMA
-burns (3RD DEGREE; MUCH OF THE BODY)
-crush injuries
-surgical procedures ✅INJURY causing SIRS
•Neutrophils entrapment- first responders in the immune system response- release too
many of them- so not helpful anymore and get in the way and too crowded
•Endothelium damage- fluid seeps out
-release of mediators
, -hypermetabolism
-Activation of coagulation cascade
*hypotension, decreased perfusion, microemboli, and redistributed or shunted blood
flow eventually comprimise organ perfusion ✅Pathophysiology of MODS
•Dilated- and have damage that allows the fluid to seep out causing edema in the
tissues
•Neutrophils- traffic and crowding ✅SIRS PATHO: Capillary Permeability
*2 out of 4 criteria*
-Temp > 38 ºC (100.5º F) or < 36 ºC (96.8º F)
-Respiratory rate> 20 or PaCO2 <32 (why is CO2 low? Blowing off so much)
-Heart rate >90
-White blood cells >12,000 or <4,000 or >10% bands (immature WBC) ✅SIRS Criteria
Sepsis ✅SIRS + confirmed Infection (culture)=
Septic Shock ✅Sepsis + LOW B/P despite fluids
*failure of two or more organ systems
-MODS mortality rates are 70% to 80% when three or more organ systems fail
-Results from SIRS
-Associated with widespread endothelial and cell injury
-Homeostasis cannot be maintained without intervention
-The respiratory system is often the first system to show signs of dysfunction in SIRS
and MODS, often culminating in acute respiratory distress syndrome (ARDS).
-Cardiovascular changes, neurologic dysfunction, acute kidney injury, DIC, GI
dysfunction, and liver dysfunction are common
*•When it gets to 3 or more organ failures, you're SOL (crap out of luck)
•They have to have LOTSSSS of interventions ✅Multiple organ dysfunction syndrome
(MODS)
-Direct damage to the endothelium --> Increase in vascular permeability --> Mediators
and protein leak out of endothelium into interstitial space --> Hypotension and
decreased perfusion ✅Patho of SIRS: RELEASE OF MEDIATORS
Formation of microemboli ✅Patho of MODS: Activation of coagulation cascade
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