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NPLEX 2 Pharmacology Full (Elective and Core) Study Guide (Latest Update 2025)
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NPLEX 2 Pharmacology Full (Elective and Core) Study Guide (Latest Update 2025)
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NPLEX 2 Pharmacology Full (Elective andCore) Study Guide (Latest Update 2025)
*5-fluorouracil - Correct Answer ✅Antineoplastic,
antimetabolite
MOA:
interferes with DNA synthesis [S phase]
blocks deoxyuridylic acid to thymidylic acid
also interferes with RNA synthesis
Uses:
palliative tx of carcinoma of colon, rectum, breast, stomach
or pancreas
topically: BCC
SE:
leukopenia, thrombocytopenia, GI ulceration, bleeding,
hemorrhage
NVD
stomatitis
local inflammatory sensitivity rxn
,NPLEX 2 Pharmacology Full (Elective and
Core) Study Guide (Latest Update 2025)
Interaction:
may inc warfarin effects
reduce response to vaccines
CI:
topical application to mucous membranes, exposure to
sunlight
depressed bone marrow fnx
poor nutritional status
pregnancy and lactation category D
*Amantadine - Correct Answer ✅Antiviral, antiparkinson
MOA: Antagonist of NMDA glutamate receptor, weak DA
agonist, prevents release of infectious viral nucleic acid
Use: Anti viral, but mostly anti-parkinson- not recommended
for influenza A, herpes zoster in immunocompromised
,NPLEX 2 Pharmacology Full (Elective and
Core) Study Guide (Latest Update 2025)
SE: CNS such as anxiety and difficulty swallowing. , seizures.
Interactions: CNS stimulants, antimuscarinics,
anticholinergics [enhances effects of all]
CI: hypersensitivity, seizure d/o, pregnancy C and lactation-
enters breast milk
untreated narrow angle glaucoma
severe renal impairment, gastric ulceration
*Amiodarone - Correct Answer ✅Antiarrhythmic agent
MOA:
blocks K, Na, Ca channels
blocks adrenergic B receptors
prolongs cardiac repolarization
negative chronotropic
inc PR and QT intervals
, NPLEX 2 Pharmacology Full (Elective and
Core) Study Guide (Latest Update 2025)
Uses:
supraventricular and ventricular arrhythmias
V-tach
A-fib
SE:
Pulmonary fibrosis
cornea/skin deposits-> blue-gray skin
liver toxicity
heart block
hypotension
hypo/hyperthyroidism
Interactions:
**digoxin, cyclosporine, phenytoin, other antiarrhythmics
antihypertensives [b blockers, CCBs]
**Hypericum- may inc metabolism and decrease drug
effectiveness
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