Genetic Research in Human Populations (ID 6)
Important Considerations in Genetic Research
1. Effects on Family Members - IRB Consideration: - ️ When conducting research that involves collecting biological specimens for genetic testing, the
effects of findings on other family members is the ...
Genetic Research in Human Populations (ID 6)
Important Considerations in Genetic Research
1. Effects on Family Members
- IRB Consideration:
- ✔️ When conducting research that involves collecting biological specimens for genetic testing, the
effects of findings on other family members is the most important issue for the IRB to consider.
- Rationale:
- While all issues are significant, the potential impact of research findings on family members takes
precedence.
2. Biospecimen Use and De-Identification
- Research Focus by Investigator A:
- Conducts research on emphysema using biospecimens.
- Consent form specifies research will focus exclusively on emphysema.
- Use by Investigator B:
- Wishes to use de-identified specimens for lung cancer research.
- Can Investigator B proceed without re-consent?
- ✔️ Yes, if the biospecimens are de-identified, then the research is no longer considered human
subjects research.
- Ethical Concerns:
- Many commentators find it ethically problematic to use specimens in ways inconsistent with the
informed consent language, despite regulations allowing de-identification.
3. Definition of Genetic Determinism
- Best Definition:
- ✔️ Genes are primarily responsible for human traits, including health, behavior, and disease.
- Current Understanding:
- Genetic determinism suggests genes control health and behavior; however, current thinking
emphasizes the complex interplay between genes and environmental factors.
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