1. Which Drugs Will Go Through A Pharmaceutic Phase After It Is Administered?
a. Intramuscular Cephalosporins
b. Intravenous Vasopressors
c. Oral Analgesics
d. Subcutaneous
Antiglycemics
ANSWER: C
When Drugs Are Administered Parenterally, There Is No Pharmaceutic Phase, Which Occurs
When A Drug Becomes A Solution That Can Cross The Biologic Membrane.
2. The Nurse Is Preparing To Administer An Oral Medication And Wants To Ensure A
Rapid Drug Action. Which Form Of The Medication Will The Nurse Administer?
a. Capsule
b. Enteric-Coated Pill
c. Liquid Suspension
d. Tablet
ANSWE
R: C
Liquid Drugs Are Already In Solution, Which Is The Form Necessary For Absorption In The
GI Tract. The Other Forms Must Disintegrate Into Small Particles And Then Dissolve Before
Being Absorbed.
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3. The Nurse Is Teaching A Patient Who Will Be Discharged Home With A Prescription For An
Enteric- Coated Tablet. Which Statement By The Patient Indicates Understanding Of The
Teaching?
a. I May Crush The Tablet And Put It In Applesauce To Improve Absorption.
b. I Should Consume Acidic Foods To Enhance Absorption Of This Medication.
c. I Should Expect A Delay In Onset Of The Drugs Effects After Taking The Tablet.
d. I Should Take This Medication With High-Fat Foods To Improve Its
Action. ANSWER: C
Enteric-Coated Tablets Resist Disintegration In The Acidic Environment Of The Stomach And
Disintegrate When They Reach The Small Intestine. There Is Usually Some Delay In Onset Of
Actions After Taking These Medications. Enteric-Coated Tablets Should Not Be Crushed Or
Chewed, Which Would Alter The Time And Location Of Absorption. Acidic Foods Will Not
Enhance The Absorption Of The Medication. The Patient Should Not To Eat High-Fat Food
Before Ingesting An Enteric-Coated Tablet, Because High-Fat Foods Decrease The Absorption
Rate.
4. A Patient Who Is Newly Diagnosed With Type 1 Diabetes Mellitus Asks Why Insulin Must
Be Given By Subcutaneous Injection Instead Of By Mouth. The Nurse Will Explain That This
Is Because
a. Absorption Is Diminished By The First-Pass Effects In The Liver.
b. Absorption Is Faster When Insulin Is Given Subcutaneously.
c. Digestive Enzymes In The Gastrointestinal Tract Prevent Absorption.
d. The Oral Form Is Less Predictable With More Adverse
Effects. ANSWER: C
Insulin, Growth Hormones, And Other Protein-Based Drugs Are Destroyed In The Small Intestine
By Digestive Enzymes And Must Be Given Parenterally. Because Insulin Is Destroyed By
Digestive Enzymes, It Would Not Make It To The Liver For Metabolism With A First-Pass Effect.
Subcutaneous Tissue Has Fewer Blood Vessels, So Absorption Is Slower In Such Tissue. Insulin
Is Given Subcutaneously Because It Is Desirable To Have It Absorb Slowly.
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