NAPLEX MOA BEST GRADED EXAM
QUESTION LATEST VERSION 2024
adapalene - CORRECT ANSWER-topical retinoid for acne
brimonidine ophth (Alphagan) - CORRECT ANSWER-adrenergic alpha-2 agonist for
glaucoma (reduce aqueous humor production and increase aqueous outflow)
phenazopyridine (pyridium) - CORRECT ANSWER-Urinary analgesic to treat dysuria
(pain or burning with urination) during UTI
testosterone topical (Androgel) - CORRECT ANSWER-testosterone replacement for
hypogonadism
gatifloxacin (zymar) - CORRECT ANSWER-quinolone antibiotic (inhibit bacterial DNA
topo IV and DNA gyrase which prevents supercoiling of DNA and promotes breakage of
ds DNA)
moxifloxacin ophthalmic (vigamox) - CORRECT ANSWER-quinolone antibiotic (inhibit
bacterial DNA topo IV and DNA gyrase which prevents supercoiling of DNA and
promotes breakage of ds DNA)
clindamycin - CORRECT ANSWER-lincosamide antibiotic (binds to 50S subunit of the
bacterial ribosome inhibiting protein synthesis)
mupirocin topical - CORRECT ANSWER-Topical Antibiotic for eradication and minor
wounds
,lacosamide (vimpat) - CORRECT ANSWER-Narrow-spectrum antiepileptic (stabilizes
hyperexcitable neuronal membranes and inhibits repetitive neuronal firing by enhancing
the slow inactivation of Na channels)
levetiracetam - CORRECT ANSWER-Broad-spectrum antiepileptic (Increases GABA
and is also a Ca channel blocker = slows down or stops transmission of the electrical
signal)
Used for focalized and generalized seizures
oxcarbazepine (trileptal) - CORRECT ANSWER-Narrow-spectrum antiepileptic/Na
channel blocker (decreases neurons firing rate)/Ca channel blocker (slows down or
stops transmission of the electrical signal)
gabapentin (neurontin) - CORRECT ANSWER-Miscellaneous antiepileptic/GABA
analog (However, it does not bind to GABA-A or GABA-B receptors, & does not appear
to influence synthesis or uptake of GABA. High affinity gabapentin binding sites in the
brain correspond to the presence of voltage-gated Ca channels specifically possessing
the alpha-2-delta-1 subunit. This channel is located presynaptically, and may modulate
the release of excitatory NTs which participate in epileptogenesis & nociception)
Used in epilepsy
Used as pain mgmt adjuvant (neuropathic)
diphenoxylate/atropine - CORRECT ANSWER-Antidiarrheal agents (diphenoxylate is an
antimotility agent that slows intestinal motility prolong water reabsorption in the gut.
Atropine is an anticholinergic agent)
Used for diarrhea and IBS-D
metoclopramide (reglan) - CORRECT ANSWER-Antiemetic agent/DA receptor
antagonist (blocks DA receptors int he CNS including the CTZ. Also enhances response
to ACh in the upper GI tract, causing enhanced motility, accelerated gastric emptying
and increase LES tone which decreases GERD sx)
Used in CINV
Also used in GERD + gastroparesis
nystatin topical - CORRECT ANSWER-miscellaneous systemic nonabsorbed/Partially
Absorbed antifungal agent (Binds to sterols in fungal cell membrane, changing the cell
wall permeability allowing for leakage of cellular contents)
, colchicine - CORRECT ANSWER-Antigout Agent (disrupts cytoskeletal functions by
inhibiting β-tubulin polymerization into microtubules, preventing activation,
degranulation, and migration of neutrophils associated with mediating some gout
symptoms)
anastrozole (arimidex) - CORRECT ANSWER-Aromatase inhibitor (decreases
production of estrogen and testosterone)
Used in breast cancer
benzonatate - CORRECT ANSWER-Cough suppressant (for nonproductive cough) for
cough/cold (suppresses cough by anesthetic action on the respiratory stretch receptors)
Used for temporary relief of cough and upper respiratory tract symptoms associated
with allergy or the common cold
alendronate oral (fosamax) - CORRECT ANSWER-bisphosphonate (inhibit osteoclast
activity and bone resorption)
Used for osteoporosis
ibandronate oral/injection (boniva) - CORRECT ANSWER-bisphosphonate (inhibit
osteoclast activity and bone resorption)
Used for osteoporosis
risedronate oral (actonel) - CORRECT ANSWER-bisphosphonate (inhibit osteoclast
activity and bone resorption)
Used for osteoporosis
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