BCH 369 CHAPTER 7 TEST QUESTIONS
WITH ANSWERS ALL REVISED AND
UPDATED
random mechanism - Answer-A multisubunit reaction without a compulsory order of
substrate binding to the enzyme.
ordered mechanism - Answer-A multisubunit reaction with a compulsory order of
substrate binding to the enzyme.
Ping pong mechanism - Answer-An enzymatic reaction in which one or more products
are released before all the substrates have bound to the enzyme.
allosteric enzyme - Answer-1
cooperativity - Answer-2
rational drug design - Answer-The synthesis of more effective drugs based on detailed
knowledge of the target molecule's structure and function.
pharmacokinetics - Answer-The behavior of a drug in the body, including its metabolism
and excretion.
clinical trial - Answer-A three-phase series of tests of a drug's safety and effectiveness
in human subjects.
Irreversible inhibitor - Answer-A molecule that binds to and permanently inactivates an
enzyme.
suicide substrate - Answer-A molecule that chemically inactivates an enzyme only after
undergoing part of the normal catalyric reaction.
competitive inhibition - Answer-A form of enzyme inhibition in which a substance
competes with the substrate for binding to the enzyme active site and thereby appears
to increase Km.
inhibition constant (KI) - Answer-The dissociation constant for the complex between an
enzyme and a reversible inhibitor.
EI complex - Answer-The noncovalent complex that forms between an enzyme and a
reversible inhibitor.
WITH ANSWERS ALL REVISED AND
UPDATED
random mechanism - Answer-A multisubunit reaction without a compulsory order of
substrate binding to the enzyme.
ordered mechanism - Answer-A multisubunit reaction with a compulsory order of
substrate binding to the enzyme.
Ping pong mechanism - Answer-An enzymatic reaction in which one or more products
are released before all the substrates have bound to the enzyme.
allosteric enzyme - Answer-1
cooperativity - Answer-2
rational drug design - Answer-The synthesis of more effective drugs based on detailed
knowledge of the target molecule's structure and function.
pharmacokinetics - Answer-The behavior of a drug in the body, including its metabolism
and excretion.
clinical trial - Answer-A three-phase series of tests of a drug's safety and effectiveness
in human subjects.
Irreversible inhibitor - Answer-A molecule that binds to and permanently inactivates an
enzyme.
suicide substrate - Answer-A molecule that chemically inactivates an enzyme only after
undergoing part of the normal catalyric reaction.
competitive inhibition - Answer-A form of enzyme inhibition in which a substance
competes with the substrate for binding to the enzyme active site and thereby appears
to increase Km.
inhibition constant (KI) - Answer-The dissociation constant for the complex between an
enzyme and a reversible inhibitor.
EI complex - Answer-The noncovalent complex that forms between an enzyme and a
reversible inhibitor.
