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HSS 3305 Lecture #7 Test With Complete Solution
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HSS 3305 Lecture #7 Test WithComplete Solution
Two branches of adaptive immunity - Answer humoral and cell mediated
Humoral immunity involves ___ cells - Answer B cells
Cell mediated immunity involved ___ cells - Answer T cells (CD4, CD8)
Humoral immunity is the main defence against... - Answer viruses, fungi, parasites,
some bacteria
Mechanism by which the body rejects transplanted organs is ____ immunity - Answer
cell mediated
Means of eliminating abnormal cells that arise spontaneously in cell division (cancer) is
____ immunity - Answer cell mediated
Entry of a foreign antigen into the body triggers a chain of 3 events - Answer recognition
of foreign antigen
proliferation of individual lymphocytes that are programmed to respond to the antigen to
form a large group of cells
destruction of pathogen cells by lymphocytes
Interaction of humoral and cell-mediated immunity - Answer T lymphocytes proliferate,
form a diverse population of cells that regulate the immune response & generate a CM
immune rxn to eliminate antigen (CD4/8)
B lymphocytes proliferate, mature into antibody forming plasma cells & require CD4T
help
Both will retain some as memory cells
What is the T lymphocyte response to an antigen? - Answer Unable to respond to a
foreign antigen until a macrophage or dendritic cell has phagocytosed, digested, and
displayed on its cell membrane the antigen fragments combined with MHC
What is the B lymphocyte response to an antigen? - Answer They have immunoglobulin
molecules (BCR) on their cell membranes that function as antigen receptors
Can bind entire antigen molecules to receptors
Don't need MHC
, Antibodies are globulins produced by... - Answer plasma cells
Antibodies can react with... - Answer only the specific antigen that induced its formation
Functions of antibodies - Answer activation of complement
neutralization
agglutination
opsonization
An antibody is ___ shaped before binding to an antigen - Answer T
An antibody is ___ shaped as it binds to an antigen - Answer Y
An antigen binds to the ___ of an antibody - Answer arms
Antibody types (5) - Answer IgG, IgA, IgM, IgE, IgD
Structure and function of IgG antibody - Answer Structure: monomer (Y), smaller
Function: principal antibody molecule in response to majority of infectious agents
The antibody that has the largest quantity in the blood - Answer IgG
Structure and function of IgM antibody - Answer Structure: large macroglobulin,
expressed on surface as monomer, secreted as pentamer
Function: immune control in early response, very efficient combining with fungi
Structure and function of IgE antibody - Answer Structure: monomer (Y)
Function: increased concentration in allergic individuals, controls parasitic infections,
binds to mast cells & basophils/eosinophils
Structure and function of IgA antibody - Answer Structure: dimer
Function: produced by antibody-forming cells located in respiratory & GI tract,
combines with harmful ingested or inhaled antigens to form antigen-antibody complexes
Structure and function of IgD antibody - Answer Structure: monomer (Y)
Function: found on cell membrane of B lymphocytes, present in minute quantities in
blood
Naive B cells have what antibodies on their surface? - Answer IgM, IgD
Without T cell help, antibody production is... - Answer weak, short lived, no memory
Immune system methods of control (4) - Answer cytokines (direct/control immune
response)
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