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PMY 302 EXAM 1 DRUGS QUESTIONS WITH COMPLETE ANSWERS $7.99
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PMY 302 EXAM 1 DRUGS QUESTIONS WITH COMPLETE ANSWERS
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therefore, increase CO but doesn't change BP bc not much effect on B2 albuterol - B-AR agonist Affinity: B2>>>> B1 Examples of drug/food- drug interactions in Type A ADRS - viagra and nitrates - severe hypotension warfarin and heparin - bleeding alcohol and acetaminophen - increas...

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  • September 1, 2024
  • 10
  • 2024/2025
  • Exam (elaborations)
  • Questions & answers

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  • PMY 302 DRUGS
  • PMY 302 DRUGS

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PMY 302 EXAM 1 DRUGS
therefore, increase CO but doesn't change BP bc not much effect on B2

albuterol - B-AR agonist

Affinity: B2>>>> B1



Examples of drug/food- drug interactions in Type A ADRS - viagra and nitrates - severe
hypotension

warfarin and heparin - bleeding

alcohol and acetaminophen - increase CYP2E1 toxin

grapefruit - inhibits C450 which inc plasma drug conc




Benadryl vs Advil PM

minodoxil - treat hypertension but topically used for hair growth



loniten vs rogaine

Examples of Type A ADRs - sulbutamol- bronchi dilates in lungs at B2 but cause tachycardia on B1
in the heart



NSAID - reduces inflammation at COX2 but causes gastric ulcers at COX1



Acetaminophen- causes liver toxin CYP2E1- alcohol can increase this



Digoxin and erythromycin - cause increase in digoxin toxicity

Examples of Type B ADRs - Hypersensitivity- tinnitus after single aspirin pill



Idiosyncratic - giving sulfonamide to some G6PD deficient causes hemolysis

haloperidol - Type A ADRs , can cause tardive dyskinesia

, used for schizophrenia

Example of pharmacogenetics on Type A ADRs - polymorphism of N-acetyl transferase (NAT) - ADR
on pharmacokinetics example : slow acetylators causes decrease in hepatic elimination

Choline acetyl transferase - makes Ach

Phenylethanoamine N-methyltransferase - Make EPI from NE

commonality between somatic, PNS and SNS is: - first synapse uses Ach nicotinic receptors

pilocarpine - Muscarinic agonist - used in open angled glaucoma - causes miosis in the eye

echothiophate - AchE inhibitor used in open angled glaucoma

Ach IV : high vs low dose - high : will cause decrease in HR, BP and CO



low : will cause tachycardia - why?

diphenhydramine - suppress edema, pruritis and causes drowiness



At low dose, Ach has a higher affinity for M3 endothelial receptors. These cause an activation in NO
which will cause vasodilation thus decreasing BP. Then you will get a reflex to get tachycardia

cholinergic esters ( Ach muscarinic) agonist - Ach

methacholine

carbachol

bethanechol

oxotremorine

cevimeline

Bethanechol - pure muscarinic agonist , resistant to AchE because has a NH2+ group

carbachol - strong nicotinic agonist, resistant to AchE because has a NH2+ group.

drug use in glaucoma - muscarinic agonist -pilocarpine or carbachol



or



AchE inhibitor - physostigmine and organophosphate (echothiophate)

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