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PMY 302 EXAM 1 DRUGS with complete solutions
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PMY 302 EXAM 1 DRUGS with complete PMY 302 EXAM 1 DRUGS with complete solutionssolutions
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PMY 302 EXAM 1 DRUGS with completesolutions
diphenhydramine - ANSWER- suppress edema, pruritis and causes drowiness
Benadryl vs Advil PM
minodoxil - ANSWER- treat hypertension but topically used for hair growth
loniten vs rogaine
Examples of Type A ADRs - ANSWER- sulbutamol- bronchi dilates in lungs at B2
but cause tachycardia on B1 in the heart
NSAID - reduces inflammation at COX2 but causes gastric ulcers at COX1
Acetaminophen- causes liver toxin CYP2E1- alcohol can increase this
Digoxin and erythromycin - cause increase in digoxin toxicity
Examples of Type B ADRs - ANSWER- Hypersensitivity- tinnitus after single
aspirin pill
Idiosyncratic - giving sulfonamide to some G6PD deficient causes hemolysis
haloperidol - ANSWER- Type A ADRs , can cause tardive dyskinesia
used for schizophrenia
, Examples of drug/food- drug interactions in Type A ADRS - ANSWER- viagra and
nitrates - severe hypotension
warfarin and heparin - bleeding
alcohol and acetaminophen - increase CYP2E1 toxin
grapefruit - inhibits C450 which inc plasma drug conc
Example of pharmacogenetics on Type A ADRs - polymorphism of N-acetyl
transferase (NAT) - ANSWER- ADR on pharmacokinetics example : slow
acetylators causes decrease in hepatic elimination
Choline acetyl transferase - ANSWER- makes Ach
Phenylethanoamine N-methyltransferase - ANSWER- Make EPI from NE
commonality between somatic, PNS and SNS is: - ANSWER- first synapse uses
Ach nicotinic receptors
pilocarpine - ANSWER- Muscarinic agonist - used in open angled glaucoma -
causes miosis in the eye
echothiophate - ANSWER- AchE inhibitor used in open angled glaucoma
Ach IV : high vs low dose - ANSWER- high : will cause decrease in HR, BP and
CO
low : will cause tachycardia - why?
At low dose, Ach has a higher affinity for M3 endothelial receptors. These cause
an activation in NO which will cause vasodilation thus decreasing BP. Then you
will get a reflex to get tachycardia
cholinergic esters ( Ach muscarinic) agonist - ANSWER- Ach
methacholine
carbachol
bethanechol
oxotremorine
cevimeline
Bethanechol - ANSWER- pure muscarinic agonist , resistant to AchE because has
a NH2+ group
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