MICR 270 Exam Prep Test with Questions and 100% Verified Answers
6 views 0 purchase
Course
MICR 270
Institution
MICR 270
Natural killer/NK cells function/characteristics - Answer - Granular lymphocytes
- Have granules containing perforin and granzymes
- Can recognize abnormal cells (tumour or virus-infected cells) and destroy them (Lack
antigen-specific receptors)
- Exception to lymphoid lineage (This is because ...
MICR 270 Exam Prep Test with Questions and
100% Verified Answers
Natural killer/NK cells function/characteristics - Answer - Granular lymphocytes
- Have granules containing perforin and granzymes
- Can recognize abnormal cells (tumour or virus-infected cells) and destroy them (Lack
antigen-specific receptors)
- Exception to lymphoid lineage (This is because their role is in innate immunity)
T cells/lymphocytes function/characteristics - Answer - Key part of cell-mediated
immunity (a subset of adaptive immunity)
- Non-phagocytic cells
- Mature in thymus
- Have specific receptors at their cell surfaces (T-cell receptors/TCR)
- Express many TCR which recognize the same specific antigen/epitope
- TCR specificity ensures each T-cell in body recognizes a different antigen
- Subsets include helper T-cell/CD4+ T-cell and cytotoxic T-cell/CD8+ T-cell
Helper T-cell/Th cell/CD4+ T-cells - Answer - Specialized T-cells (Express CD4 co-
stimulatory molecule on their cell surface)
- Activated when they recognize an antigen-MHC Class II complex
- They have effector cells: activated helper T-cells have critical role in activation of other
immune cells
- They have memory cells: activated helper T-cells can generate cells that recognize the
same specific antigen
,Cytotoxic T-cells/Tc cells/Cytotoxic T Lymphocytes (CTL)/CD8+ T-cells - Answer -
Specialized T-cells (Express CD8 co-stimulatory molecule on their cells surface)
- Activated when they recognize an antigen-MHC Class I complex
- They have effector cells: activated cytotoxic T-cells have critical role in monitoring cells
of body (They eliminate virus-infected or tumour cells)
- They have memory cells: activated cytotoxic T-cells can generate cells that recognize
the same specific antigen
B cells/lymphocytes function/characteristics - Answer - Key part of humoral immunity
(subset of adaptive immunity)
- Non-phagocytic cells
- Mature in bone marrow
- Have specific receptors at their cell surface (B-cell receptors/BCR)
- BCR are the membrane-bound form of antibodies
- Express many BCR which recognize the same specific antigen/epitope
- BCR specificity ensures each B-cell in body recognizes a different antigen
Plasmocytes/plasma cells - Answer - Effector form of activated naive B-cells
- Produce and secrete highly specialized antibodies (These can bind free pathogens or
foreign molecules in the organism)
- B-cell activation can also generate memory cells which recognize the same specific
antigen (These memory cells have membrane-bound antibodies (BCR) with same
specificity as mother cell)
Primary lymphoid organs - Answer - Thymus
- Bone Marrow
Differences in function between primary and secondary lymphoid organs - Answer - The
primary lymphoid organs are the site of lymphocyte maturation into an
immunocompetent cell (The B-cells mature in the bone marrow, T cells mature in the
thymus)
- The secondary lymphoid organs are the site of lymphocyte activation into an effector
cell (This occurs through interaction with trapped antigens)
Thymus identifiers - Answer - Has flat bi-lobed structure (Each lobe divided into lobules;
Each lobule divided into cortex and medulla compartments)
- Filled with thymocytes, epithelial cells, dendritic cells and macrophages
- Situated above the heart
Bone marrow identifiers - Answer - Made up of flexible tissue
- Divided into yellow and red marrow
- Filled with hematopoietic cells
- Found in the central cavity inside bones
Spleen identifiers - Answer - Have large, ovoid structure
- Divided into white and red pulp compartments
- Situated in the left abdominal cavity
Lymph node identifiers - Answer - Have a small, bean-shaped structure (1-25 mm)
- Numerous (~ 600 in body)
- Divided into 3 roughly concentric regions (Cortex, paracortex and medulla)
- Filled with lymphocytes, macrophages and dendritic cells
, - Found grouped along the lymphatic vessels
MALT identifiers - Answer - Filled with various immune cells
- Found in mucous membranes lining digestive, respiratory and urogenital systems
Thymus function - Answer - Site of T-cell development and maturation
Bone marrow function - Answer - Red marrow (Site of hematopoiesis and B-cell
development)
- Yellow marrow (Some leukocyte development; Produces fat and cartilage)
Spleen function - Answer - Red pulp (filters the blood)
- White pulp (site of development of immune responses against antigens found in the
bloodstream)
Lymph node function - Answer - Filters the lymph
- Often the first organized lymphoid structure foreign molecules encounter (upon
entering the body)
MALT function - Answer - Initiates immune responses to specific antigens encountered
along all mucosal surfaces
Immune system discrimination and elimination - Answer - A main function of the
immune system is discrimination and elimination of non-self and altered self cells
- Discrimination occurs as immune cells distinguish between self and non-self
components
- Elimination occurs as immune cells initiate an immune response
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller Examsplug. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $13.99. You're not tied to anything after your purchase.
