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MRCP Official Sample Questions

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D: transient Mobitz type 1 atrioventricular block E: ventricular premature beats E: ventricular premature beats - answer-C A 28-year-old man presented with a 1-month history of weight loss, abdominal distension, flatulence and foul-smelling diarrhoea following a visit to India. anti-t...

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  • September 3, 2024
  • 104
  • 2024/2025
  • Exam (elaborations)
  • Questions & answers
  • MRCP Official
  • MRCP Official
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MRCP Official Sample Questions and answers
A 65-year-old woman presented with a 12-hour history of the sudden onset of gait unsteadiness,
vomiting and headache, followed by increasing drowsiness.

What is the most likely diagnosis?
A: acute cerebellar haemorrhage
B: acute subdural haemorrhage
C: frontal subdural empyema
D: herpes simplex encephalitis
E: pituitary apoplexy - answer-A

A post-marketing observational study of a new drug was conducted on 5000 patients following
clinical trials.

What best describes the data generated from this type of study?
A: comparative efficacy
B: cost-benefit
C: cost effectiveness
D: potency
E: profile of adverse effects - answer-E

A 79-year-old woman was admitted for elective hip replacement surgery. On examination, she
was pale. There was 2-cm splenomegaly and there were small discrete axillary lymph nodes.

haemoglobin 107 g/L (115-165)
white cell count 34.5 × 109/L (4.0-11.0)
platelet count 183 × 109/L (150-400)

What is the most likely diagnosis?
A: acute myeloid leukaemia
B: chronic lymphocytic leukaemia
C: chronic myeloid leukaemia
D: myelodysplasia
E: myelofibrosis - answer-B

A 17-year-old boy presented with a non-blanching rash over his legs, a swollen knee and
painless, visible haematuria.

Urinalysis showed blood 3+, protein 1+.

serum creatinine 210 µmol/L (60-110) urine culture negative ultrasound scan of kidneys normal


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What glomerular abnormality is most likely to be present at renal biopsy?

A: focal segmental sclerosis

B: foot process fusion

C: linear deposition of IgG on the basement membrane

D: mesangial deposition of IgA

E: thickening of basement membranes - answer-D

A 75-year-old woman developed a spreading cellulitis on her left leg secondary to ulceration.

blood cultures MRSA

In addition to vancomycin, what is the most appropriate antibiotic?

A: amoxicillin

B: azithromycin

C: flucloxacillin

D: metronidazole

E: rifampicin - answer-E

A 45-year-old woman presented with right flank pain. She had a 4-year history of hypertension
and progressive cognitive impairment.

On examination, she had livedo reticularis and tenderness in the right flank. Her BP was 185/105
mmHg. Urinalysis showed blood 3+, protein 1+.

Hb 129 g/L (115-165) WCC 8.7 × 109/L (4.0-11.0) PlTs 83 × 109/L (150-400)

serum creatinine 106 µmol/L (60-110)

What antibody test is most likely to be positive?

A: anticardiolipin

B: anticentromere



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C: anti-glomerular basement membrane

D: antimitochondrial

E: anti-neutrophil cytoplasmic

E: anti-neutrophil cytoplasmic - answer-A

A 37-year-old woman presented with a history of intermittent lightheadedness. Examination was
normal.ECG normal

24-hour ambulatory ECG tracing
atrial and ventricular premature beats; nocturnal bradycardia and Mobitz type 1 atrioventricular
block, and supraventricular tachycardia

Which abnormality on the 24-hour ambulatory ECG is clinically most important?

A: atrial premature beats

B: profound sleep-associated bradycardia

C: supraventricular tachycardia

D: transient Mobitz type 1 atrioventricular block

E: ventricular premature beats

E: ventricular premature beats - answer-C

A 28-year-old man presented with a 1-month history of weight loss, abdominal distension,
flatulence and foul-smelling diarrhoea following a visit to India.

anti-tissue transglutaminase antibodies negative

stool cultures and microscopy negative

What is the most likely diagnosis?

A: acute HIV seroconversion illness

B: coeliac disease

C: giardiasis

D: hookworm infection (ancylostomiasis)
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E: viral gastroenteritis - answer-C

A 30-year-old woman presented with a 6-month history of tremor and difficulty in speaking.

On examination, she was found to have increased muscle tone in all four limbs, bradykinesia and
4-cm hepatomegaly.

What laboratory finding would best support a diagnosis of Wilson's disease?

A: increased incorporation of radioactive copper into caeruloplasmin

B: low hepatic copper content

C: low serum caeruloplasmin concentration

D: low serum free copper concentration

E: low urine copper concentration - answer-C

Question 10

What dietary substrate is broken down into glucose and galactose by the action of intestinal
enzymes?
A: fructose

B: lactose

C: maltose

D: mannose

E: sucrose - answer-B

A 16-year-old girl presented with non-scaly, discrete areas of hair loss on the scalp. She had a
past history of atopic eczema and had a number of depigmented areas on her hands and around
her eyes.

What is the most likely diagnosis?

A: alopecia areata

B: hypothyroidism



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