NR565 / NR 565 MIDTERM EXAM
STUDY GUIDE (LATEST ):
ADVANCED PHARMACOLOGY
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Beer's Criteria- What is it and Why is it important Recommendations of medications
inappropriate for elderly (65 and older)
Prevents adverse drug reactions
Impacts/outcomes of polypharmacy -increase risk for medication interactions
CYP450 inhibitors
o Examples
o What do they do?
, o What do they cause if not used correctly? (aka: What would the patient experience?) inhibit
metabolism, increase blood levels of medications
Examples
Valproate, isoniazid, sulfonamides, amiodarone, chloramphenicol, ketoconazole, grapefruit juice,
quinidine
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Examples of CYP450 inducers
o Examples
o What do they do?
o What do they cause if not used correctly? (aka: What would the patient experience?) Speed up
metabolism of drugs (drug is cleared faster), drug has lesser effect (decrease blood levels of drug)
Examples
Barbituates, St John wort, Carbamazepine, rifampin, alcohol, phenytoin, griseofulvin, phenobarbital,
sulfonylureas
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What happens when someone has a poor metabolism phenotype? medications metabolized
slower, medication might not work or put them at risk for side-effects
What does the U.S. Food and Drug Administration regulate when it comes to medications?
Whether the drug is safe, effective, and benefits of a drug outweigh the risks
Which schedule drugs can APRNs prescribe? II-V
Who determines and regulates prescriptive authority? State Board of Nursing
How does limited prescriptive authority impact patients within the healthcare system? Longer wait
times to sign a prescription
Limit practitioners that are needed in rural areas
Unequal relationships between providers.
Independent practitioners= more patients being seen= lessens the patient/provider load
What are the key responsibilities of prescribing? Safe and competent practice
Understanding of the drugs, reactions, and pharmacology
Be aware of the age group you are prescribing to
What should be used to make prescribing decisions? Documented provider-patient relationship
