BOC Immunology Training Exam Questions Solved Correctly.
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Course
Boc serology immunology
Institution
Boc Serology Immunology
b (lupus erythematosus) - Answer 1) Antinuclear antibody tests are performed to help diagnose?
a) acute leukemia
b) lupus erythematosus
c) hemolytic anemia
d) Crohn disease
c (Crithida lucilia) - Answer 2. In the anti-double-stranded DNA procedure, the antigen most commonly utilized is...
BOC Immunology Training Exam
Questions Solved Correctly.
b (lupus erythematosus) - Answer 1) Antinuclear antibody tests are performed to help diagnose?
a) acute leukemia
b) lupus erythematosus
c) hemolytic anemia
d) Crohn disease
c (Crithida lucilia) - Answer 2. In the anti-double-stranded DNA procedure, the antigen most commonly
utilized is:
a. rat stomach tissue
b. mouse kidney tissue
c. Crithida lucilia
d. Toxoplasma gondii
c (diagram C) - Answer 3) Which of the ANA patterns shown above would be associated with high titers
of antibodies to the Sm antigen?
a) diagram A
b) diagram B
c) diagram C
d) diagram D
b (5°C +/- 2°) - Answer 4) Sera to be tested for IFA-ANA 6 days after drawing is best stored at?
a) room temperature
b) 5°C +/- 2°
c) -70°C in a constant temperature freezer
,d) -20°C in a frost-free self-defrosting freezer
a (rim) - Answer 5) Antibodies directed at native DNA are most frequently associated with which
pattern of fluorescence in the IFA-ANA test?
a) rim
b) diffuse
c) speckled
d) centromere
b (expected for anti-DNA antibodies) - Answer 6) The technologist observes apparent homogenous
staining of the nucleus of interphase cells while performing an IFA-ANA, as well as staining of the
chromosomes in mitotic cells. This result is:
a) indicative of 2 antibodies, which should be separately reported after titration
b) expected for anti-DNA antibodies
c) inconsistent; the test should be reported with new reagent
d) expected for anti-centromere antibodies
a (anti-dsDNA titer 1:80, and a high titer of antibodies to Sm) - Answer 7) The result of an anti-nuclear
antibody test was a titer of 1:320 with a peripheral pattern. Which of the following sets of results best
correlate with these results?
a) anti-dsDNA titer 1:80, and a high titer of antibodies to Sm
b) antimitochondrial antibody titer 1:160, and antibodies to RNP
c) anti-Scl-70, and antibodies to single-stranded DNA
d) high titers of anti-SS-A and anti-SS-B
a (high titers of DNA antibody) - Answer 8) Systemic lupus erythematosus patients often have which of
the following test results?
a) high titers of DNA antibody
b) decreased serum immunoglobulin levels
c) high titers of anti-smooth muscle antibodies
d) high titers of antimitochondrial antibody
,c (marked decrease in serum CH50) - Answer 9. Systemic lupus erythematosus patients with active
disease often have which of the following test results?
a. high titers of antimicrosomal antibodies
b. high titers of anti-smooth muscle antibodies
c. marked decrease in serum CH50
d. decreased serum immunoglobulin levels
c (complement (C3)) - Answer 10. Which of the following is decreased in serum during the active stages
of systemic lupus erythematosus?
a. anti-nuclear antibody
b. immune complexes
c. complement (C3)
d. anti-DNA
c (CREST syndrome) - Answer 11. A positive ANA with the pattern of anticentromere antibodies is most
frequently seen in patients with:
a. rheumatoid arthritis
b. systemic lupus erythematosus
c. CREST syndrome
d. Sjӧgren syndrome
DNA - Answer 12. In the indirect fluorescent anti-nuclear antibody test, a homogenous pattern
indicates the presence of antibody to:
a. RNP
b. Sm
, c. RNA
d. DNA
b (Sm) - Answer 13. In the indirect fluorescent anti-nuclear antibody test, a speckled pattern may
indicate the presence of antibody to:
a. histone
b. Sm
c. RNA
d. DNA
c (lupus erythematosus) - Answer 14) A patient has the following test results:
The above results could be seen in patients with:
a) rheumatic fever
b) rheumatoid arthritis
c) lupus erythematosus
d) glomerulonephritis
a (mixed connective tissue disease) - Answer 15. Autoantibodies in the absence of Sm are found in
patients with:
a. mixed connective tissue disease
b. systemic lupus erythematosus
c. Crohn disease
d. multiple myeloma
a (nephelometry) - Answer 16) Which of the following is the most sensitive and appropriate method
for the detection of rheumatoid factor?
a) nephelometry
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