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NR566 Final (Advanced Pharmacology for Care of the Family)Questions & Answers(RATED A+) $12.49   Add to cart

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NR566 Final (Advanced Pharmacology for Care of the Family)Questions & Answers(RATED A+)

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Anti-Androgens - ANSWER Finasteride (Propecia) Leuprolide (Eligard, Lupron, Lupron Depot) Spironolactone (Aldactone) Finasteride (Propecia, Proscar) - ANSWER blocks conversion of testosterone to dihydrotesterone Used to tx: -BPH -male pattern baldness 3 months of therapy need to see...

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  • September 4, 2024
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NR566 Final (Advanced
Pharmacology for Care of the
Family)Questions &
Answers(RATED A+)

Anti-Androgens - ANSWER Finasteride (Propecia)

Leuprolide (Eligard, Lupron, Lupron Depot)

Spironolactone (Aldactone)



Finasteride (Propecia, Proscar) - ANSWER blocks conversion of testosterone to dihydrotesterone



Used to tx:

-BPH

-male pattern baldness

3 months of therapy need to see benefits

Stopping, reverses effect w/in 12 months



Adverse side effects:

- Decreased libido

-Impotence



dutasteride (Avodart) - ANSWER 5-alpha reductase inhibitor

used to tx:

BPH

,Can stay in serum up to 6 mon after discontinuing



can be absorbed through skin

pregnant woman shouldn't handle capsules

(fetal anomaly in male fetus)



Adverse Effects

decreased libido

Impotence



Leuprolide Acetate (Lupron) - ANSWER Luteinizing hormone - releasing agonist

create reversible:

-orchiectomy state

-oophorectomy state



Used to tx:

- advanced prostatic cancer

- Management of endometriosis

- Uterine fibroids

- polycystic ovarian disease

- central precocious puberty in peds



Flutamide (Eulexin, Euflex) - ANSWER Truly non-steroidal agent

Used to tx:

-Advanced prostate cancer

-female androgen excess syndrome



Adverse Effects in males

- gynecomastia

-reversible liver toxicity

, Black Box Warning

-hepatic failure

-hepatic encephalopathy

Basline/monthly liver function test for 1st 4 months



Spironolactone (Aldactone) - ANSWER aldosterone antagonist

potassium sparing diuretic



used for tx:

-female hirsutism (abnormal growth of hair)

-acne

-relief of PMS/PMDD symptoms (25-50 mg/d)



Adverse reactions

- dose related + reversible when discont.

-GI upset

-Drowsiness

-Gynecomastia

-Impotence

-Cutaneous (skin) eruptions

- Urticaria



Black Box Warning

Tumorigenicity in animals

Should not be used during pregnancy



Androgen - ANSWER Testosterone

most important adrogen in humans

levels remain stable at 55yr

70 yrs men decrease in

-strength, libido, muscle mass

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