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NAPLEX Exam Review - Pharmacy Foundations.pdf 2024 /2025 100% correct
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NAPLEX EXAm REviEw - PhARmAcy FouNdAtioNs1. What is the primary NT of the somatic nervous system and what
receptors does it bind?: correct answer
ACh
nicotinic (skeletal muscle)
2. parasympathetic nervous system NT/receptors/effects: ACh muscarinic
SLUDD: correct answer salivation, lacrimation, urination,
defecation, digestion "rest and digest"
3. sympathetic nervous system NTs/receptors/effects: correct answer Epi/NE alpha/beta
(adrenergic)
‘ BP, HR, bronchodilation
4. muscarinic agonists (2) and antagonists (2): agonists: pilocarpine, bethane- chol
antagonists: atropine, oxybutynin
,5. nicotinic agonist and antagonist: agonist: nicotine antagonist: rocuronium
6. ±-1agonists (2) and antagonists (3), actions: peripheral
agonists: phenylephrine, DA (dose-dependent) ’ smooth muscle
vasoconstriction antagonists: doxazosin, carvedilol, phentolamine ’ vasodilation
7. ±-2agonists (2) and antagonists (2), actions: brain/CNS agonists: clonidine,
brimonidine ’ decrease Epi/NE release antagonists: ergot alkaloids, yohimbine
8. ²-1agonists (3) and antagonists (3): heart
agonists: dobutamine, isoproterenol, DA (dose-
dependent) antagonists: metoprolol, propranolol,
carvedilol
9. ²-2agonists (3) and antagonists (2): lungs agonists: albuterol,
terbutaline, isoproterenol antagonists: propranolol, carvedilol
10. DA agonists (2) and antagonists (2): renal, CV, CNS agonists: levodopa,
pramipexole
antagonists: FGAs/haloperidol, metoclopramide
11. 5HT agonist (1) and antagonists (2): platelets, GI, CNS agonists: triptans
antagonists: ondansetron, SGAs/quetiapine
12. AChEIs (3), action: donepezil, rivastigmine, galantamine block breakdown of ACh
,(Alzheimer's)
13. ACEI effects: decrease vasoconstriction and aldosterone release (HTN, HF, CKD)
14. COMT inhibitor, effect: entacapone block breakdown
of levodopa (PD)
, 15. NSAID action, effect: block COX from converting arachidonic acid to prostaglandins (inflammation)
and TXA2 (platelet aggregation)
16. MAOIs (7), action, effects: phenelzine, tranylcypromine, isocarboxazid, selegi- line, rasagiline, methylene blue,
linezolid
- block breakdown of catecholamines (DA, NE, Epi, 5HT)
- additive increase ’ HTN crisis
- increased 5HT ’ serotonin syndrome
17. PDE-5 inhibitors, effect: -afil
block breakdown of cGMP for prolonged smooth muscle relaxation (ED)
18. warfarin action: blocks vitamin K epoxide reductase ’ Vit K not active ’ reduced clotting factors
19. xanthine oxidase inhibitor, efffect: allopurinol
blocks breakdown of hypoxanthine/xanthine to uric acid (gout)
20. how to tell an ester vs amide anesthetic: amide has "I" before -caine
21. hydroxyl/alcohol (primary): neutral
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