Anticoagulants are commonly used for
ACS
prevention of cardioembolic stroke
prevention/treatment of VTE
Venous thrombus embolism includes
deep vein thrombosis
Pulmonary embolism
Factors that can lead to coagulation
blood vessel injury
blood stasis
prothrombotic conditions
...
Naplex -
Anticoagulation
Questions and
answers
Arrhythmias - NAPLEX
Anticoagulants are commonly used for - answer ACS
prevention of cardioembolic stroke
prevention/treatment of VTE
Venous thrombus embolism includes - answer deep vein thrombosis
Pulmonary embolism
Factors that can lead to coagulation - answer blood vessel injury
blood stasis
prothrombotic conditions
Coagulation cascase can occur via these two pathways - answer
contact activation - intrinsic
Tissue activation - extrinsic
,Function of clotting factor XA - answer Converts prothrombin ->
thrombin IIA
Function of thrombin IIa - answer Converts fibrinogen to fibrin which
links together to form clots
Warfarin targets these clotting factors - answer II (2)
VII (7)
IX (9)
X (10)
CG targeted by vitamin K
Heparin targets these clotting factors - answer CA
thrombin IIa
LMWH targets XA more than IIa
XA inhibitor agents - answer Direct:
Rivaroxaban (xarelto)
Apixaban (eliquis)
Edoxaban (savaysa)
Betrixaban (Bevyxa)
Indirect:
Fondaparinux via antithrombin
Direct thrombin inhibitor agents - answer IV: argatroban/bivalirudin
PO: dabigatran
, antithrombin function - answer inactivates thrombin and other
proteases involved in blood clotting
IV DTI are useful since they - answer do not interact with heparin
induced thrombocytopenia antibodies
Argatroban is generally the DOC
The joint commission's national patient safety goals requires that
protocols are in place so that patients who initiate anticoagulant
therapy have a - answer standardized order,dispensing,
administration, monitoring, and designated patient/caregiver
Heparin dosing of VTE prophylaxis - answer 5000 UNITS sc Q8-12H
Heparin dosing of VTE treatment - answer 80 units/kg iv bolus
followed by 18 units/kg/hour
Heparin treatment dose for ACS/STEMI - answer 60 units/kg IV
bolus, 12 units/kg/hr (max 1000 units/hr) infusion
use actual body weight for sing
Heparin lock flushes are used to - answer keep iv lines open
Heparin CI - answer uncontrolled active bleed
hypersensitivity to pork products
Heparin SE - answer bleeding (epistaxis/ecchymosis/gingival/GI)
thrombocytopenia
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