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Pathology MRCS B Exam Questions and Answers (Latest Update 2024)
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Pathology MRCS B Exam Questions and Answers (Latest Update 2024)
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Pathology MRCS B Exam Questions andAnswers (Latest Update 2024)
What is amyloid - Correct Answer ✅ Abnormally folded
proteins
They stick together and form B-Sheet
These extra deposits stick in extracellular space
What are types of amyloidosis - Correct Answer ✅
Systemic
- AL Amyloidosis (light chains misfold and build)
- AA Amlyloidosis
(serum amyloid A misfolded - acute phase reactant
IBD/RA/Ca/Mediterraean fever)
Localised
How does amyloid affect kidneys - Correct Answer ✅
Damage podocytes and cause nephrotic snd
(hypoalbuminaemia/proteinurea/edema/hyperlipidemia)
How does amyloid affect heart - Correct Answer ✅
restrictive cardiomyopathy (stiffness)
,Pathology MRCS B Exam Questions and
Answers (Latest Update 2024)
arrythmias
How does the amyloid affect intenstines - Correct Answer
✅ tips of intestinal villi
Nutrients in stool
Whereas does amyloid deposit - Correct Answer ✅ liver,
spleen, tongue
enlarged
peripheral nerves and autonomic nerves (gut, BP)
How does alzheimers relate to amyloidosis - Correct Answer
✅ AB Peptides stick around neurones and blood vessels
- local amyloidosis
How is amyloidosis diagnosed - Correct Answer ✅ Biopsy
and Congo red stain
or green under polarised light
,Pathology MRCS B Exam Questions and
Answers (Latest Update 2024)
Treatment of amyloidosis - Correct Answer ✅ Transplant
that organ
What is amyloidosis VIVA - Correct Answer ✅ Rare life-
threatening disease
Deposition of Abnormal Fibrillar Proteins "Amyloid"
in Extracellular Tissue
Deposited in a Beta-Pleated Sheet structure
Why are humans subject to amyloidosis - Correct Answer
✅ NO ENZYME to break down protein structure
Histological features of amyloidosis - Correct Answer ✅
CONGO RED stain appears APPLE GREEN bifringence
under polarised light
Tissues appear violet-blue when exposed to iodine + dilute
acid
, Pathology MRCS B Exam Questions and
Answers (Latest Update 2024)
Classification of amyloid - Correct Answer ✅ AL amyloid
(primary)
AA amyloid
Hereditary ATTR amyloid (autosomal dominant most
commonly due to transthyretin mutation)
What is AL amyloid - Correct Answer ✅ Misfolded Light
chains of immunoglobulins
"amyloid of immune origin"
Clonal proliferation of plasma cells - amyloid monoclonal Igs
Heart, Kidney, Peripheral nerves, Skin, GI tract
What is AA amyloid - Correct Answer ✅ "amyloid of chronic
inflammation"
Macrophages > Interleukins > Hepatocytes > Serum amyloid
protein A
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