"Lumpy-bumpy" appearance of glomeruli on immunofluorescence
- ANSWER ✔ Poststerptococcal glomerulonephritis (immune
complex deposition of IgG and C3b)
Lytic ("hole-punched") bone lesions on x-ray - ANSWER ✔
Multiple myeloma
Mammary gland ("blue-domed") cyst - ANSWER ✔ Fibrocystic
change of the breast
Monoclonal antibody spike - ANSWER ✔ 1. Multiple myeloma
(called the M protein; usually IgG or IgA)
2. Monoclonal gammopathy of undetermined significance
(MGUS); normal consequence of aging)
3. Waldenstrom's (M protein = IgM) macroglobulinemia
4. Primary amyloidosis
Monoclonal globulin protein in blood/urine - ANSWER ✔ Bence
Jones proteins (multiple myeloma [kappa or lambda Ig light
chains in urine]), Waldenstrom's macroglobinemia (IgM)
Mucin-filled cell with peripheral nucleus - ANSWER ✔ Signet ring
(gastric carcinoma)
Narrowing of bowel lumen on barium radiograph - ANSWER ✔
"String sign" (Crohn's disease)
Periosteum raised from bone, creating triangular area - ANSWER
✔ Codman's triangle on x-ray (osteosarcoma, Ewing's sarcoma,
pyogenic osteomyelitis)
Podocyte fusion of EM - ANSWER ✔ Minimal change disease
(child with nephrotic syndrome)
Polished, "ivory-like" appearance of bone at cartilage erosion -
ANSWER ✔ Eburnation(osteoarthritis resulting in bony sclerosis)
Protein aggregates in neurons from hyperphosphorylation of
protein tau - ANSWER ✔ Neurofibrillary tangles (Alzheimer's
disease and Creuzfeldt Jakob disease)
Ring-enhancing brain lesions in AIDS - ANSWER ✔ Toxoplasma
gondii
Sheets of medium-sized lymphoid cells ("starry sky" appearance
on histology) - ANSWER ✔ Burkitt's lymphoma (t[8:14] c-myc
activation, associated with EBV; "black sky" made up of malignant
cells)
Silver-staining spherical aggregation of tau proteins in neurons -
ANSWER ✔ Pick bodies (Pick's disease: progressive dementia,
changes in personality)
"Soap bubble" in femur or tibia on x-ray - ANSWER ✔ Giant cell
tumor of bone (generally benign)
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