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PHCY 402 - Cephalosporins Exam Study Guide
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PHCY 402 - CephalosporinsExam Study Guide
less - Answer cepham nucleus has (more/less) ring strain than a penam nucleus
true - Answer T/F: all clinically used ceph's are semisynthetic
aminopenicillins - Answer cephalosporins have similar spectrum to _____
less (act on Pen'ase+ strains) - Answer cephalosporins are (more/less) reactive with
penicillinases
1st - Answer ___ generation cephs: best activity against G+, moderate spectrum, most
frequent dosing;
2nd - Answer ___ generation cephs: extended G- spectrum, stability to some
cephalosporinases, less frequent dosing
3rd - Answer ___ generation cephs: broad G- spectrum, some activity against
pseudomonas, stable to many cephalosporinases
5th - Answer Which generation of cephs shows activity against MRSA
Cephalexin - Answer Which ceph has the exact same side chain as ampicillin
cephalexin (keflex, keftab) - Answer 1st gen ceph, PO, QID, used to treat mild/moderate
UTI, RTI, otitis media; spectrum like augmentin
cefadroxil - Answer 1st gen ceph, PO, BID-QID; spectrum/treatment similar to
cephalexin
cefadroxil & cefprozil - Answer Which cephs have the same side chain as amoxicillin
cefazolin (ancef, kefzol) - Answer parenteral first gen ceph; used to treat severe
infections and surgical prophylaxis
more water soluble side chains - Answer What makes cefazolin able to be administered
parenterally
cefaclor - Answer 2nd gen ceph, PO; has chlorine to increase absorption
cefuroxime axetil (ceftin) - Answer 2nd gen ceph, PO; 1st line agent for lyme disease,
food increases absorption
ceftin - Answer Which 2nd generation cephalosporin is a prodrug
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