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PHCY 402- Tetracyclines Exam Latest Update
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PHCY 402- Tetracyclines ExamLatest Update
Tetracyclines are used against broad Gram +/- _____ - Answer parasites
Tetracyclines are (static/cidal) - Answer static
Tetracycline structures are made up of ____ rings - Answer four
Tetracyclines (reversibly/irreversibly) binds the the __ site of the ____ ribosome - Answer
reversibly; A; 30S
T/F: tetracyclines are the only drugs that bind 30S subunit - Answer false
(aminoglycosides also)
Tetracycline prefer which type of environment: acidic, basic, or neutral? - Answer acidic
Tetracyclines can undergo a process called ____ where they bind with metal cations and
become inactive - Answer chelation
two ways tetracyclines would get into G+ - Answer passive diffusion & active transport
How do hydrophilic tetracyclines get into G- - Answer pores
How do lipophilic tetracyclines get into G- - Answer diffuse through membrane
resistance that causes tetracycline to be dislodged from its binding site - Answer Tet(O)
major resistance associated with tetracyclines - Answer efflux
T/F: tetracyclines can be given to pregnant women - Answer false (crosses the placenta;
also excreted in breast milk)
tetracyclines have (good/bad) CNS penetration - Answer bad (would NOT be used for
meningitis, etc)
Tetracyclines cause problems with teeth because they bind ______ and cause
discoloration - Answer calcium
What type of tetracycline product would cause Fanconi-like syndrome? - Answer
expired (out of date)
Two things that happen to expired tetracyclines that lead to renal toxicity - Answer
dehydration & epimerization
tetracycline side effect due to accumulation in the skin - Answer phototoxicity (abnormal
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