PHGY 209 - Blood 3 Exam Study
Guide
Hormonal effects on erythropoietin - Answer 1. testosterone
2. Estrogen
functions of testosterone - Answer 1. increases the release of Erythropoietin
2. Increases sensitivity of RBC precursors to Erythropoietin
function of estrogen - Answer hormone that has opposite effects of testosterone
How do old RBCs get removed? - Answer removed by Macrophages (in liver and spleen)
cycle of RBCs - Answer 1. Bone marrow produces RBCs
2. ~120 days in circulation
3. Old RBCs removed and recycled by Macrophages
4. components are spread out into the right places
5. Hb --- Heme ---- Bilirubin (1 mg/dL) into the liver and then to the intestinal tract （feces
）
6. Fe (iron) --- transferrin --- Ferritin storage (in liver, spleen and gut) ---- back to bone
marrow
high in Bilirubin (胆红素) results in jaundice (黄疸)
Phototherapy - Answer a therapy that involves repeated exposure to bright light
-- heal jaundice
causes of jaundice - Answer 1. Excessive Hemolysis ---- increase Bilirubin > 1mg/dL
2. Liver damage
3. bile duct obstruction (阻碍)
Normal and Abnormal Dynamics for RBCs - Answer normal: production = destruction
abnormal:
1. production > destruction --- polycythemia (红细胞增多)
Guide
Hormonal effects on erythropoietin - Answer 1. testosterone
2. Estrogen
functions of testosterone - Answer 1. increases the release of Erythropoietin
2. Increases sensitivity of RBC precursors to Erythropoietin
function of estrogen - Answer hormone that has opposite effects of testosterone
How do old RBCs get removed? - Answer removed by Macrophages (in liver and spleen)
cycle of RBCs - Answer 1. Bone marrow produces RBCs
2. ~120 days in circulation
3. Old RBCs removed and recycled by Macrophages
4. components are spread out into the right places
5. Hb --- Heme ---- Bilirubin (1 mg/dL) into the liver and then to the intestinal tract （feces
）
6. Fe (iron) --- transferrin --- Ferritin storage (in liver, spleen and gut) ---- back to bone
marrow
high in Bilirubin (胆红素) results in jaundice (黄疸)
Phototherapy - Answer a therapy that involves repeated exposure to bright light
-- heal jaundice
causes of jaundice - Answer 1. Excessive Hemolysis ---- increase Bilirubin > 1mg/dL
2. Liver damage
3. bile duct obstruction (阻碍)
Normal and Abnormal Dynamics for RBCs - Answer normal: production = destruction
abnormal:
1. production > destruction --- polycythemia (红细胞增多)
