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APHA NAPLEX REVIEW QUESTIONS AND ANSWERS WITH SOLUTIONS 2024
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APHA NAPLEX REVIEW QUESTIONS AND ANSWERS WITH SOLUTIONS 2024
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APHA NAPLEX REVIEW QUESTIONSAND ANSWERS WITH SOLUTIONS 2024
IfOtheOpkaOofOaOweakOacidOisO2.5,OatOwhichOpHOwillOthisOdrugObecomeOmoreOionized?
A.OpHO5
B.OpHO2.5
C.OpHO1.5
D.OpHO1O-OANSWEROA.OForOaOweakOacid,OaOhigherOpHOincreasesOionization
WhichOequationOdescribesOtheOrateOofOdrugOdissolutionOfromOaOtablet?
A.OFick'sOLaw
B.OHenderson-HasselbalchOequation
C.OMichaelis-MentenOequation
D.ONoyes-WhitneyOequationO-OANSWEROD.OTheONoyes-
WhitneyOequationOdescribesOtheOrateOofOdrugOdissolutionOfromOaOtablet.OFick'sOfirstOlawOofOdiffusionOisOsi
milarOtoOtheONoyes-
WhitneyOequationOinOthatObothOequationsOdescribeOdrugOmovementOattributableOtoOaOconcentrationOgra
dient.OTheOMichealis-MentenOequationOinvolvesOenzymeOkinetics,OwhereasOHenderson-
HasselbalchOequationsOareOusedOforOdeterminationOofOpHOofOtheObufferOandOtheOextentOofOionizationOofOa
OdrugOmolecule
TheOpHOofOaObufferOsystemOcanObeOcalculatedOwith
A.OtheOHenderson-HasselbalchOequation
B.OtheONoyes-WhitneyOequation
C.OtheOMichealis-MentionOequation
D.OYong'sOequationO-OANSWEROA.OTheOHenderson-
HasselbalchOequationOformOaOweakOacidOandOitsOsaltOisOrepresentedOasOpHO=OpkaO+OlogO([salt]/[acid]),Owhe
reOpkaOisOtheOnegativeOlogOofOtheOdissolutionOconstantOofOaOweakOacid,OasO[salt]/[acid]OisOtheOratioOofOtheO
molarOconcentrationOofOsaltOandOacidOusedOtoOprepareOaObuffer
,IfOtheOpkaOofOaOdrugOisO5,OatOwhichOofOtheOfollowingOpHOvaluesOdoOtheOionicOandOnonionicOformsOofOtheOdr
ugOexistOatOequalOratio?
A.OpHO1
B.OpHO5
C.OpHO7
D.OpHO9O-OANSWEROB.OWhenOtheOpHO=Opka,OtheOratioOofOionizedOtoOun-ionizedObecomesOtheOsame
WhatOisObioavailability?
A.OBioavailabilityOisOtheOmeasurementOofOtheOrateOandOextentOofOactiveOdrugOthatOreachesOtheOsystemicOc
irculation
B.OItOisOtheOrelationshipObetweenOtheOphysicalOandOchemicalOpropertiesOofOaOdrugOandOitsOsystemicOabsor
ption
C.OItOisOtheOmovementOofOtheOdrugOintoObodyOtissuesOoverOtime
D.OItOisOtheOdissolutionOofOtheOdrugOinOtheOGIOtractO-
OANSWEROA.OBioavailabilityOisOtheOmeasurementOofOtheOrateOandOextentOofOsystemicOcirculationOofOanOact
iveOdrug
WhichOofOtheOfollowingOmayObeOusedOtoOassessOtheOrelativeObioavailabilityOofOtwoOchemicallyOequivalentO
drugOproductsOinOaOcrossoverOstudy?
A.ODissolutionOtest
B.OPeakOconcentration
C.OTime-to-peakOconcentration
D.OAreaOunderOtheOplasma-levelOtimeOcurveO-
OANSWEROD.OTheOplasmaOdrugOconcentrationOversusOtimeOcurveOmeasuresOtheObioavailabilityOofOaOdrugOf
romOaOproduct.OTheOpeakOplasmaOdrugOconcentrationO(Cmax)OrelatesOtoOtheOintensityOofOtheOpharmacolo
gicOresponse,OwhileOtheOtimeOforOpeakOplasmaOdrugOconcentrationO(Tmax)OrelatesOtoOtheOrateOofOsystemic
Oabsorption
,WhatOconditionOusuallyOincreasesOtheOrateOofOdrugOdissolutionOforOaOtablet?
A.OIncreaseOtheOparticleOsizeOofOtheOdrug
B.ODecreaseOtheOsurfaceOareaOofOtheOdrug
C.OUseOofOionized,OorOsalt,OformOofOtheOdrug
D.OUseOofOtheOfreeOacidOorOfreeObaseOformOofOtheOdrugO-
OANSWEROC.OTheOionized,OorOsalt,OformOofOaOdrugOisOgenerallyOmoreOwaterOsolubleOandOthereforeOdissolve
sOmoreOrapidlyOthanOtheOnonionizedO(freeOacidOorOfreeObase)OformOofOtheOdrug.OAccordingOtoOtheONoyes-
WhitneyOequation,OtheOdissolutionOrateOisOdirectlyOproportionOtoOtheOsurfaceOareaOandOinverselyOproporti
onalOtoOtheOparticleOsize.OTherefore,OanOincreaseOinOtheOparticleOsizeOorOaOdecreaseOinOtheOsurfaceOareaOsl
owsOtheOdissolutionOrate
IfOtheOpkaOofOaOweakObaseOdrugOisO8.3,OatOwhichOofOtheOfollowingOpHOvaluesOdoesOthisOdrugObecomeOmor
eOionized?
A.OpHO4
B.OpHO9
C.OpHO10
D.OpHO13O-OANSWEROA.OForOaOweakObase,OaOlowerOpHOvalueOincreaseOionizationOofOtheOmolecule
WhichOofOtheOfollowingOdosageOformsOmayOuseOsurface-activeOagentsOinOtheirOformulations?
A.OEmulsions
B.OSuspensions
C.OColloidalOdosageOforms
D.OCreams
E.OAllOofOtheOAboveO-
OANSWEROE.OSurfaceOactiveOagentsOfacilitateOemulsionOformationObyOloweringOtheOinterfacialOtensionObet
weenOtheOoilOandOwaterOphases.OAdsorptionOofOsurfactantsOonOinsolubleOparticlesOenablesOtheseOparticle
sOtoObeOdispersedOinOtheOformOofOaOsuspension
WhichOofOtheOfollowingOstatementsOaboutOlyophilicOcolloidalOdispersionsOisOtrue?
, A.OTheyOtendOtoObeOmoreOsensitiveOtoOtheOadditionOofOelectrolytesOthanOdoOlyophobicOsystems
B.OTheyOtendOtoObeOmoreOviscousOthanOlyophobicOsystems
C.OTheyOcanObeOprecipitatedObyOprolongedOdialysis
D.OTheyOseparateOrapidlyO-
OANSWEROB.OMostOlyophilicOcolloidsOareOorganicOmoleculesO(includingOgelatinOandOacacia);OtheyOspontane
ouslyOformOcolloidalOsolutionsOandOtendOtoObeOviscous.ODispersionOofOlyophilicOcolloidsOisOstableOinOtheOpr
esenceOofOelectrolytes
WhichOofOtheOfollowingOisOnotOtrueOforOtabletOformulations?
A.OAOdisintegratingOagentOpromotesOgranuleOflow
B.OLubricantsOpreventOadherenceOofOgranulesOtoOtheOpunchOfacesOofOtheOtabletingOmachine
C.OGlidantsOpromoteOflowOofOtheOgranules
D.OBindingOagentsOareOusedOforOadhesionOofOpowderOintoOgranulesO-
OANSWEROA.ODisintegratingOagentsOareOaddedOtoOtheOtabletsOtoOpromoteObreakupOofOtheOtabletsOwhenOpl
acedOinOtheOaqueousOenvironment.OLubricantsOareOrequiredOtoOpreventOadherenceOofOtheOgranulesOtoOth
eOpunchOfacesOandOdies.OGlidantsOareOaddedOtoOtabletOformulationsOtoOimproveOtheOflowOpropertiesOofOth
eOgranulations.OBindingOagentsOareOaddedOtoObindOpowdersOtogetherOinOtheOgranulationOprocess
TheOabsorptionOrateOofOaOdrugOisOmostOrapidOwhenOtheOdrugOisOformulatedOas
A.OaOcontrolled-releaseOproduct
B.OaOhardOgelatinOcapsule
C.OaOcompressedOtablet
D.OaOsolutionO-
OANSWEROD.OForOaOdrugOinOsolution,OnoOdissolutionOisOrequiredObeforeOabsorption.OConsequently,Ocompa
redOwithOotherOdrugOformulations,OaOdrugOinOaqueousOsolutionOhasOtheOhighestObioavailabilityOrateOandOis
OoftenOusedOasOtheOreferenceOpreparationOforOotherOformulations
AccordingOtoOtheONoyes-
WhitneyOequation,OtheOdrugOconcentrationOimmediatelyOatOtheOsolidOsurfaceOwithinOtheOdiffusionOlayerO(
stagnantOlayer)OisOrecognizedOasOthe
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