What is the primary organ where valproic acid is toxic? - - correct
answer ✅Liver (hepatoxicity)
What are 4 signs of hepatoxicity? - - correct answer ✅Abdominal pain
in the RUQ
Reddish-brown urine
Yellowing of the skin/sclera
Fatigue
What is the therapeutic range for valproic acid? - - correct answer
✅50-125 mcg/ml
What is a toxic level of valproic acid? - - correct answer ✅>150 mcg/ml
,Georgette's - LMR final Exam Questions
And Answers
What are 4 signs of valproic acid toxicity? - - correct answer
✅Disorientation
Lethargy
Respiratory depression
Nausea/vomiting
A patient on depakote complains of abdominal pain in the RUQ and
reddish-brown urine. What do you suspect? What do you do? - - correct
answer ✅Suspect: hepatotoxicity
Interventions:
-hold med
-draw LFT's (priority)
-VPA/DVP level
With suspected toxicity with valproic acid, what steps/labs should be
drawn? - - correct answer ✅D/C drug
Check drug level
Obtain LFTs
Obtain ammonia level
, Georgette's - LMR final Exam Questions
And Answers
A pregnant patient is taking accutane, zyprexa, and abilify. What
medication needs to be discontinued? - - correct answer ✅Accutane
Accutane is used for acne and is contraindicated in pregnancy as it can
cause birth defects
What herbal supplement is used for anxiety, stress, and insomnia? - -
correct answer ✅Kava Kava
What is a major side effect of Kava Kava? - - correct answer ✅Liver
damage
What drugs should be avoided with Kava Kava? - - correct answer
✅Alprazolam
CNS depressants (e.g., phenobarbital, zolpidem)
What are 5 symptoms of Stephen's Johnson Syndrome (SJS)? - - correct
answer ✅Key symptoms:
-Fever
-Burning of mouth/eyes
Additional symptoms:
Body aches
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