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PMD 605 Drug Actions I M4 Product Dissolution Exam Study Set
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PMD 605 Drug Actions I M4 Product Dissolution Exam Study Set ...
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PMD 605 Drug Actions I M4Product Dissolution Exam Study
Set
what is dissolution? - Answer process by which a solid phase goes into liquid phase (e.g.
water, buffer)
what is dissolution testing? - Answer it is used throughout lifestyle of solid dosage forms
in order to evaluate the rate of release of drug from dosage form
what is drug release? - Answer process by which a drug substance leaves a drug
product and is subjected to absorption, distribution, metabolism, and excretion,
ultimately becoming available for pharmacologic action
what is the difference between drug product and drug substance? - Answer - drug
product is a dosage form (e.g. capsule, tablet) containing the drug substance and
usually some associated ingredient(s) (i.e. excipients)
- drug substance - contained in a tablet (i.e. dosage form) and is an active
pharmaceutical ingredient intended to provide pharmacologic activity
what is immediate release dosage form? - Answer it is a dosage form that allows the
drug to dissolve in GI tract without delaying or prolonging dissolution or absorption of
the drug
what is the modified release dosage form? - Answer dosage forms whose drug-release
characteristics of time and/or location are chosen to accomplish therapeutic or
convenience objectives not offered by conventional dosage forms.
what are the two forms of modified release dosage form? - Answer extended release
and delayed release
what is extended release dosage form? - Answer dosage forms formulated to make the
drug available over an extended period after ingestion, allowing reduction in dosing
frequency compared to a drug presented as conventional dosage form
what is delayed release dosage form? - Answer - dosage form that releases its contents
quickly after a set period or delay during which there is no drug released. e.g. enteric
coated dosage form
what is enteric coated dosage form? - Answer those that delay the release of drug until
dosage form has passed through the stomach
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